Assessment of trabecular meshwork width using swept source optical coherence tomography

Tin A. Tun, Mani Baskaran, Ce Zheng, Lisandro M. Sakata, Shamira A. Perera, Anita S. Chan, David S Friedman, Carol Y. Cheung, Tin Aung

Research output: Contribution to journalArticle

Abstract

Purpose: Measurements of the angle width by ultrasound biomicroscopy or anterior segment optical coherence tomography are usually performed 500 μm from the scleral spur, as the anterior part of trabecular meshwork (TM) is assumed to lie within this distance. The aim of this study was to measure TM width using swept source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan), and to investigate factors influencing this measurement. Methods: Participants underwent gonioscopy and SS-OCT imaging in the dark. High-definition SS-OCT images were corrected for refractive distortion; and customized software (ImageJ; National Institutes of Health, Bethesda, MD, USA) was utilized to measure TM width (distance between the scleral spur and Schwalbe's line). Linear regression analysis was performed to assess the relationship between TM width with demographic and angle parameters. Results: One hundred and forty eight Chinese subjects were analyzed. The majority was female (62.4 %); the mean age was 59.2 ± 8.68 years. Identification of the scleral spur and Schwalbe's line with SS-OCT was possible in 590 (99.7 %) and 585 angle quadrants (98.8 %) respectively. TM width was wider in the inferior and superior quadrants (mean 889 [SD 138] and 793 [136] μm), compared to the nasal and temporal quadrants (712 [137] and 724 [115] μm, P <0.001). There was a difference in average TM width between open (789 [100]) and closed angle eyes (753 [86]) (P = 0.048). There was no significant association between TM width and angle parameters, laterality, or demographic factors. Conclusions: In SS-OCT HD images, the mean TM width varied from 710 to 890 μm in the different quadrants of the eye, and the inferior quadrant TM was the widest compared to other quadrants.

Original languageEnglish (US)
Pages (from-to)1587-1592
Number of pages6
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume251
Issue number6
DOIs
StatePublished - Jun 2013

Fingerprint

Trabecular Meshwork
Optical Coherence Tomography
Gonioscopy
Demography
Acoustic Microscopy
National Institutes of Health (U.S.)
Nose
Linear Models
Japan
Software
Regression Analysis

Keywords

  • Angle closure
  • Quantitative angle measurements
  • Swept source optical coherence tomography
  • Trabecular meshwork

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Assessment of trabecular meshwork width using swept source optical coherence tomography. / Tun, Tin A.; Baskaran, Mani; Zheng, Ce; Sakata, Lisandro M.; Perera, Shamira A.; Chan, Anita S.; Friedman, David S; Cheung, Carol Y.; Aung, Tin.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 251, No. 6, 06.2013, p. 1587-1592.

Research output: Contribution to journalArticle

Tun, Tin A. ; Baskaran, Mani ; Zheng, Ce ; Sakata, Lisandro M. ; Perera, Shamira A. ; Chan, Anita S. ; Friedman, David S ; Cheung, Carol Y. ; Aung, Tin. / Assessment of trabecular meshwork width using swept source optical coherence tomography. In: Graefe's Archive for Clinical and Experimental Ophthalmology. 2013 ; Vol. 251, No. 6. pp. 1587-1592.
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abstract = "Purpose: Measurements of the angle width by ultrasound biomicroscopy or anterior segment optical coherence tomography are usually performed 500 μm from the scleral spur, as the anterior part of trabecular meshwork (TM) is assumed to lie within this distance. The aim of this study was to measure TM width using swept source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan), and to investigate factors influencing this measurement. Methods: Participants underwent gonioscopy and SS-OCT imaging in the dark. High-definition SS-OCT images were corrected for refractive distortion; and customized software (ImageJ; National Institutes of Health, Bethesda, MD, USA) was utilized to measure TM width (distance between the scleral spur and Schwalbe's line). Linear regression analysis was performed to assess the relationship between TM width with demographic and angle parameters. Results: One hundred and forty eight Chinese subjects were analyzed. The majority was female (62.4 {\%}); the mean age was 59.2 ± 8.68 years. Identification of the scleral spur and Schwalbe's line with SS-OCT was possible in 590 (99.7 {\%}) and 585 angle quadrants (98.8 {\%}) respectively. TM width was wider in the inferior and superior quadrants (mean 889 [SD 138] and 793 [136] μm), compared to the nasal and temporal quadrants (712 [137] and 724 [115] μm, P <0.001). There was a difference in average TM width between open (789 [100]) and closed angle eyes (753 [86]) (P = 0.048). There was no significant association between TM width and angle parameters, laterality, or demographic factors. Conclusions: In SS-OCT HD images, the mean TM width varied from 710 to 890 μm in the different quadrants of the eye, and the inferior quadrant TM was the widest compared to other quadrants.",
keywords = "Angle closure, Quantitative angle measurements, Swept source optical coherence tomography, Trabecular meshwork",
author = "Tun, {Tin A.} and Mani Baskaran and Ce Zheng and Sakata, {Lisandro M.} and Perera, {Shamira A.} and Chan, {Anita S.} and Friedman, {David S} and Cheung, {Carol Y.} and Tin Aung",
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T1 - Assessment of trabecular meshwork width using swept source optical coherence tomography

AU - Tun, Tin A.

AU - Baskaran, Mani

AU - Zheng, Ce

AU - Sakata, Lisandro M.

AU - Perera, Shamira A.

AU - Chan, Anita S.

AU - Friedman, David S

AU - Cheung, Carol Y.

AU - Aung, Tin

PY - 2013/6

Y1 - 2013/6

N2 - Purpose: Measurements of the angle width by ultrasound biomicroscopy or anterior segment optical coherence tomography are usually performed 500 μm from the scleral spur, as the anterior part of trabecular meshwork (TM) is assumed to lie within this distance. The aim of this study was to measure TM width using swept source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan), and to investigate factors influencing this measurement. Methods: Participants underwent gonioscopy and SS-OCT imaging in the dark. High-definition SS-OCT images were corrected for refractive distortion; and customized software (ImageJ; National Institutes of Health, Bethesda, MD, USA) was utilized to measure TM width (distance between the scleral spur and Schwalbe's line). Linear regression analysis was performed to assess the relationship between TM width with demographic and angle parameters. Results: One hundred and forty eight Chinese subjects were analyzed. The majority was female (62.4 %); the mean age was 59.2 ± 8.68 years. Identification of the scleral spur and Schwalbe's line with SS-OCT was possible in 590 (99.7 %) and 585 angle quadrants (98.8 %) respectively. TM width was wider in the inferior and superior quadrants (mean 889 [SD 138] and 793 [136] μm), compared to the nasal and temporal quadrants (712 [137] and 724 [115] μm, P <0.001). There was a difference in average TM width between open (789 [100]) and closed angle eyes (753 [86]) (P = 0.048). There was no significant association between TM width and angle parameters, laterality, or demographic factors. Conclusions: In SS-OCT HD images, the mean TM width varied from 710 to 890 μm in the different quadrants of the eye, and the inferior quadrant TM was the widest compared to other quadrants.

AB - Purpose: Measurements of the angle width by ultrasound biomicroscopy or anterior segment optical coherence tomography are usually performed 500 μm from the scleral spur, as the anterior part of trabecular meshwork (TM) is assumed to lie within this distance. The aim of this study was to measure TM width using swept source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan), and to investigate factors influencing this measurement. Methods: Participants underwent gonioscopy and SS-OCT imaging in the dark. High-definition SS-OCT images were corrected for refractive distortion; and customized software (ImageJ; National Institutes of Health, Bethesda, MD, USA) was utilized to measure TM width (distance between the scleral spur and Schwalbe's line). Linear regression analysis was performed to assess the relationship between TM width with demographic and angle parameters. Results: One hundred and forty eight Chinese subjects were analyzed. The majority was female (62.4 %); the mean age was 59.2 ± 8.68 years. Identification of the scleral spur and Schwalbe's line with SS-OCT was possible in 590 (99.7 %) and 585 angle quadrants (98.8 %) respectively. TM width was wider in the inferior and superior quadrants (mean 889 [SD 138] and 793 [136] μm), compared to the nasal and temporal quadrants (712 [137] and 724 [115] μm, P <0.001). There was a difference in average TM width between open (789 [100]) and closed angle eyes (753 [86]) (P = 0.048). There was no significant association between TM width and angle parameters, laterality, or demographic factors. Conclusions: In SS-OCT HD images, the mean TM width varied from 710 to 890 μm in the different quadrants of the eye, and the inferior quadrant TM was the widest compared to other quadrants.

KW - Angle closure

KW - Quantitative angle measurements

KW - Swept source optical coherence tomography

KW - Trabecular meshwork

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