Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR tagging

Daniel B. Ennis, Frederick H. Epstein, Peter Kellman, Lameh Fananapazir, Elliot R. McVeigh, Andrew E. Arai

Research output: Contribution to journalArticle

Abstract

Diastolic and systolic left ventricular (LV) dysfunction often significantly contribute to disabling symptoms in familial hypertrophic cardiomyopathy (FHC). This study compares regional LV function (midwall circumferential strain) during systole and diastole in eight FHC patients and six normal volunteers (NVs) using MR tagging. A prospectively-gated fast gradient-echo sequence with an echo-train readout was modified to support complementary spatial modulation of magnetization (CSPAMM) tagging and full cardiac cycle data acquisition using the cardiac phase to order reconstruction (CAPTAR), thus providing tag persistence and data acquisition during the entire cardiac cycle. Total systolic strains in FHC patients were significantly reduced in septal and inferior regions (both P <0.01). Early-diastolic strain rates were reduced in all regions of the FHC group (all P <0.03). The combination of CSPAMM and CAPTOR allows regional indices of myocardial function to be quantified throughout the cardiac cycle. This technique reveals regional differences in systolic and diastolic impairment in FHC patients.

Original languageEnglish (US)
Pages (from-to)638-642
Number of pages5
JournalMagnetic Resonance in Medicine
Volume50
Issue number3
DOIs
StatePublished - Sep 1 2003

Keywords

  • Cardiomyopathy
  • Diastole
  • Hypertrophy
  • Regional
  • Tagging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Ennis, D. B., Epstein, F. H., Kellman, P., Fananapazir, L., McVeigh, E. R., & Arai, A. E. (2003). Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR tagging. Magnetic Resonance in Medicine, 50(3), 638-642. https://doi.org/10.1002/mrm.10543