Assessment of pituitary reserve in subjects pretreated with dexamethasone

Arnold M. Moses, Myron Miller

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma 17-OHCS and growth hormone responses to insulin-induced hypoglycemia and Piromen-induced fever have been determined in subjects who were acutely pretreated with dexamethasone. Dexamethasone, in the dosage used, does not interfere with the effect of insulin on the increase in plasma growth hormone or plasma 17-OHCS concentration, provided an adequate amount of insulin is used to produce the same degree of hypoglycemia as when there was no steroid pretreatment. By utilizing the hormonal responses of normal subjects, and patients with hypopituitarism, criteria have been established for classifying responses as normal, abnormal or uninterpretable. An increase in plasma 17-OHCS concentration of 7.5 μg. 100 ml. or greater following the injection of insulin was considered normal with or without overnight steroid pretreatment. A lesser increase was abnormal if the minimum blood glucose was less than 45 mg. 100 ml. and uninterpretable if the minimum blood glucose was greater than 45 mg. 100 ml. Growth hormone responses to insulin-induced hypoglycemia were similarly interpreted with a normal growth hormone rise being 7.5 mμg./ml. With or without overnight steroid pretreatment, an increase in plasma 17-OHCS concentration of greater than 7.5 μg. 100 ml. in response to Piromen was considered normal. A lesser response was abnormal if the maximum temperature was 100.5° F or greater, and uninterpretable if the maximum temperature was less. A plasma growth hormone increase of 5 mμg./ml. or greater in response to Piromen was considered normal. A lesser increase was uninterpretable.

Original languageEnglish (US)
Pages (from-to)376-386
Number of pages11
JournalMetabolism
Volume18
Issue number5
DOIs
StatePublished - May 1969
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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