Abstract
Studies have identified structural abnormalities in areas of the autistic brain, with a pattern suggesting that a neurodevelopmental anomaly took place. Neural cell adhesion molecule (NCAM), which is involved in development of the central nervous system, was previously shown to be decreased in the serum of autistic individuals. In the present study, we measured NCAM protein in the sera from controls, patients with autism, siblings of autistic patients, and individuals with other neurologic disorders, but found no significant differences. We also measured NCAM protein in autistic postmortem brain samples and found the longest isoform, NCAM-180, to be significantly decreased. In addition, we investigated the mRNA expression of NCAM in these brain samples using cDNA microarrays and RT-PCR. Results show that NCAM mRNA levels are not altered in autism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 183-194 |
| Number of pages | 12 |
| Journal | Journal of Autism and Developmental Disorders |
| Volume | 31 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2001 |
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Keywords
- Autism
- Brain
- Neural cell adhesion molecule
ASJC Scopus subject areas
- Psychology(all)
- Developmental and Educational Psychology
- Medicine(all)
Cite this
Assessment of Neural Cell Adhesion Molecule (NCAM) in Autistic Serum and Postmortem Brain. / Purcell, Amy E.; Rocco, Mary Margaret; Lenhart, Jennifer A.; Hyder, Karim; Zimmerman, Andrew W.; Pevsner, Jonathan A.
In: Journal of Autism and Developmental Disorders, Vol. 31, No. 2, 04.2001, p. 183-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of Neural Cell Adhesion Molecule (NCAM) in Autistic Serum and Postmortem Brain
AU - Purcell, Amy E.
AU - Rocco, Mary Margaret
AU - Lenhart, Jennifer A.
AU - Hyder, Karim
AU - Zimmerman, Andrew W.
AU - Pevsner, Jonathan A.
PY - 2001/4
Y1 - 2001/4
N2 - Studies have identified structural abnormalities in areas of the autistic brain, with a pattern suggesting that a neurodevelopmental anomaly took place. Neural cell adhesion molecule (NCAM), which is involved in development of the central nervous system, was previously shown to be decreased in the serum of autistic individuals. In the present study, we measured NCAM protein in the sera from controls, patients with autism, siblings of autistic patients, and individuals with other neurologic disorders, but found no significant differences. We also measured NCAM protein in autistic postmortem brain samples and found the longest isoform, NCAM-180, to be significantly decreased. In addition, we investigated the mRNA expression of NCAM in these brain samples using cDNA microarrays and RT-PCR. Results show that NCAM mRNA levels are not altered in autism.
AB - Studies have identified structural abnormalities in areas of the autistic brain, with a pattern suggesting that a neurodevelopmental anomaly took place. Neural cell adhesion molecule (NCAM), which is involved in development of the central nervous system, was previously shown to be decreased in the serum of autistic individuals. In the present study, we measured NCAM protein in the sera from controls, patients with autism, siblings of autistic patients, and individuals with other neurologic disorders, but found no significant differences. We also measured NCAM protein in autistic postmortem brain samples and found the longest isoform, NCAM-180, to be significantly decreased. In addition, we investigated the mRNA expression of NCAM in these brain samples using cDNA microarrays and RT-PCR. Results show that NCAM mRNA levels are not altered in autism.
KW - Autism
KW - Brain
KW - Neural cell adhesion molecule
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UR - http://www.scopus.com/inward/citedby.url?scp=0035317628&partnerID=8YFLogxK
U2 - 10.1023/A:1010751232295
DO - 10.1023/A:1010751232295
M3 - Article
C2 - 11450817
AN - SCOPUS:0035317628
VL - 31
SP - 183
EP - 194
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 2
ER -