Assessment of myocardial fibrosis with cardiovascular magnetic resonance

Nathan Mewton; Chia Ying Liu; Pierre Croisille; David Alan Bluemke; Joo A.C. Lima

doi:10.1016/j.jacc.2010.11.013

Assessment of myocardial fibrosis with cardiovascular magnetic resonance

Nathan Mewton, Chia Ying Liu, Pierre Croisille, David Alan Bluemke, Joo A.C. Lima

School of Medicine

Research output: Contribution to journal › Review article › peer-review

568 Scopus citations

Abstract

Diffuse interstitial or replacement myocardial fibrosis is a common feature of a broad variety of cardiomyopathies. Myocardial fibrosis leads to impaired cardiac diastolic and systolic function and is related to adverse cardiovascular events. Cardiovascular magnetic resonance (CMR) may uniquely characterize the extent of replacement fibrosis and may have prognostic value in various cardiomyopathies. Myocardial longitudinal relaxation time mapping is an emerging technique that could improve CMR's diagnostic accuracy, especially for interstitial diffuse myocardial fibrosis. As such, CMR could be integrated in the monitoring and therapeutic management of a large number of patients. This review summarizes the advantages and limitations of CMR for the assessment of myocardial fibrosis.

Original language	English (US)
Pages (from-to)	891-903
Number of pages	13
Journal	Journal of the American College of Cardiology
Volume	57
Issue number	8
DOIs	https://doi.org/10.1016/j.jacc.2010.11.013
State	Published - Feb 22 2011

Keywords

T1 mapping
cardiac magnetic resonance
late gadolinium enhancement
myocardial fibrosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacc.2010.11.013

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title = "Assessment of myocardial fibrosis with cardiovascular magnetic resonance",

abstract = "Diffuse interstitial or replacement myocardial fibrosis is a common feature of a broad variety of cardiomyopathies. Myocardial fibrosis leads to impaired cardiac diastolic and systolic function and is related to adverse cardiovascular events. Cardiovascular magnetic resonance (CMR) may uniquely characterize the extent of replacement fibrosis and may have prognostic value in various cardiomyopathies. Myocardial longitudinal relaxation time mapping is an emerging technique that could improve CMR's diagnostic accuracy, especially for interstitial diffuse myocardial fibrosis. As such, CMR could be integrated in the monitoring and therapeutic management of a large number of patients. This review summarizes the advantages and limitations of CMR for the assessment of myocardial fibrosis.",

keywords = "T1 mapping, cardiac magnetic resonance, late gadolinium enhancement, myocardial fibrosis",

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T1 - Assessment of myocardial fibrosis with cardiovascular magnetic resonance

AU - Mewton, Nathan

AU - Liu, Chia Ying

AU - Croisille, Pierre

AU - Bluemke, David Alan

AU - Lima, Joo A.C.

PY - 2011/2/22

Y1 - 2011/2/22

N2 - Diffuse interstitial or replacement myocardial fibrosis is a common feature of a broad variety of cardiomyopathies. Myocardial fibrosis leads to impaired cardiac diastolic and systolic function and is related to adverse cardiovascular events. Cardiovascular magnetic resonance (CMR) may uniquely characterize the extent of replacement fibrosis and may have prognostic value in various cardiomyopathies. Myocardial longitudinal relaxation time mapping is an emerging technique that could improve CMR's diagnostic accuracy, especially for interstitial diffuse myocardial fibrosis. As such, CMR could be integrated in the monitoring and therapeutic management of a large number of patients. This review summarizes the advantages and limitations of CMR for the assessment of myocardial fibrosis.

AB - Diffuse interstitial or replacement myocardial fibrosis is a common feature of a broad variety of cardiomyopathies. Myocardial fibrosis leads to impaired cardiac diastolic and systolic function and is related to adverse cardiovascular events. Cardiovascular magnetic resonance (CMR) may uniquely characterize the extent of replacement fibrosis and may have prognostic value in various cardiomyopathies. Myocardial longitudinal relaxation time mapping is an emerging technique that could improve CMR's diagnostic accuracy, especially for interstitial diffuse myocardial fibrosis. As such, CMR could be integrated in the monitoring and therapeutic management of a large number of patients. This review summarizes the advantages and limitations of CMR for the assessment of myocardial fibrosis.

KW - T1 mapping

KW - cardiac magnetic resonance

KW - late gadolinium enhancement

KW - myocardial fibrosis

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JO - Journal of the American College of Cardiology

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Assessment of myocardial fibrosis with cardiovascular magnetic resonance

Abstract

Keywords

ASJC Scopus subject areas

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