Assessment of Luminal and Basal Phenotypes in Bladder Cancer

Charles C. Guo, Jolanta Bondaruk, Hui Yao, Ziqiao Wang, Li Zhang, Sangkyou Lee, June Goo Lee, David Cogdell, Miao Zhang, Guoliang Yang, Vipulkumar Dadhania, Woonyoung Choi, Peng Wei, Jianjun Gao, Dan Theodorescu, Christopher Logothetis, Colin Dinney, Marek Kimmel, John N. Weinstein, David J. McConkeyBogdan Czerniak

Research output: Contribution to journalArticle

Abstract

Genomic profiling studies have demonstrated that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to frontline chemotherapy. We analyzed the mRNA expressions of signature luminal and basal genes in bladder cancer tumor samples from publicly available and MD Anderson Cancer Center cohorts. We developed a quantitative classifier referred to as basal to luminal transition (BLT) score which identified the molecular subtypes of bladder cancer with 80–94% sensitivity and 83–93% specificity. In order to facilitate molecular subtyping of bladder cancer in primary care centers, we analyzed the protein expressions of signature luminal (GATA3) and basal (KRT5/6) markers by immunohistochemistry, which identified molecular subtypes in over 80% of the cases. In conclusion, we provide a tool for assessment of molecular subtypes of bladder cancer in routine clinical practice.

Original languageEnglish (US)
Article number9743
JournalScientific reports
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2020

ASJC Scopus subject areas

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    Guo, C. C., Bondaruk, J., Yao, H., Wang, Z., Zhang, L., Lee, S., Lee, J. G., Cogdell, D., Zhang, M., Yang, G., Dadhania, V., Choi, W., Wei, P., Gao, J., Theodorescu, D., Logothetis, C., Dinney, C., Kimmel, M., Weinstein, J. N., ... Czerniak, B. (2020). Assessment of Luminal and Basal Phenotypes in Bladder Cancer. Scientific reports, 10(1), [9743]. https://doi.org/10.1038/s41598-020-66747-7