Assessment of left ventricular end-systolic elastance from aortic pressure-left ventricular volume relations

Wen Shin Lee; Masaru Nakayama; Wen Pin Huang; Kuan Rau Chiou; Chih Cheng Wu; Erez Nevo; Barry Fetics; David A. Kass; Philip Yu An Ding; C. H. Chen

doi:10.1007/s003800200003

Assessment of left ventricular end-systolic elastance from aortic pressure-left ventricular volume relations

Wen Shin Lee, Masaru Nakayama, Wen Pin Huang, Kuan Rau Chiou, Chih Cheng Wu, Erez Nevo, Barry Fetics, David A. Kass, Philip Yu An Ding, C. H. Chen

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The left ventricular (LV) end-systolic pressure-volume relation (ESPVR) is a load-insensitive method for evaluating LV contractility, which needs invasive measurement. Some noninvasive methods substitute peak aortic pressure (P_s) for end-systolic LV pressure by assuming there is no difference between these pressures. However, this assumption has not been directly validated. With conductance catheter and dual micromanometers, ESPVRs and the slope (Ees_LV) were constructed from simultaneous LV pressures (LVP) and volumes, aortic pressures (AOP) and LV volumes (Ees_AO), and P_s and LV end-ejection volumes (V_EE) (Ees_PP-_EEV) during preload reduction in 50 subjects. The ratio of steady-state P_s over V_EE (P_s/V_EE) was also checked. AOP and LVP displayed differences of 11 ± 6 and -30 ± 12 mmHg at the onset and end-ejection, respectively, and -2 ± 4 mmHg at end-systole. Ees_AO and Ees_LV were nearly identical: Ees_AO = 0.97 × Ees_LV + 0.05, r² = 0.99. Ees_PP-EEV correlated with Ees_LV (Ees_PP-EEV = 0.57 × Ees_LV + 0.61, r² = 0.46) but with much more scatter. P_s/V_EE correlated worst with Ees_LV. Central AOP can be substituted for LVP to derive Ees_LV. Other estimation methods yield weaker and poor correlations to directly measured Ees.

Original language	English (US)
Pages (from-to)	99-104
Number of pages	6
Journal	Heart and Vessels
Volume	16
Issue number	3
DOIs	https://doi.org/10.1007/s003800200003
State	Published - 2002

Keywords

Central aortic pressure
End-systolic pressure-volume relationship
Hemodynamics
Left ventricular function

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1007/s003800200003

Cite this

@article{d93eec3549f34946b29f28a2bf917a53,

title = "Assessment of left ventricular end-systolic elastance from aortic pressure-left ventricular volume relations",

abstract = "The left ventricular (LV) end-systolic pressure-volume relation (ESPVR) is a load-insensitive method for evaluating LV contractility, which needs invasive measurement. Some noninvasive methods substitute peak aortic pressure (Ps) for end-systolic LV pressure by assuming there is no difference between these pressures. However, this assumption has not been directly validated. With conductance catheter and dual micromanometers, ESPVRs and the slope (EesLV) were constructed from simultaneous LV pressures (LVP) and volumes, aortic pressures (AOP) and LV volumes (EesAO), and Ps and LV end-ejection volumes (VEE) (EesPP-EEV) during preload reduction in 50 subjects. The ratio of steady-state Ps over VEE (Ps/VEE) was also checked. AOP and LVP displayed differences of 11 ± 6 and -30 ± 12 mmHg at the onset and end-ejection, respectively, and -2 ± 4 mmHg at end-systole. EesAO and EesLV were nearly identical: EesAO = 0.97 × EesLV + 0.05, r2 = 0.99. EesPP-EEV correlated with EesLV (EesPP-EEV = 0.57 × EesLV + 0.61, r2 = 0.46) but with much more scatter. Ps/VEE correlated worst with EesLV. Central AOP can be substituted for LVP to derive EesLV. Other estimation methods yield weaker and poor correlations to directly measured Ees.",

keywords = "Central aortic pressure, End-systolic pressure-volume relationship, Hemodynamics, Left ventricular function",

author = "Lee, {Wen Shin} and Masaru Nakayama and Huang, {Wen Pin} and Chiou, {Kuan Rau} and Wu, {Chih Cheng} and Erez Nevo and Barry Fetics and Kass, {David A.} and Ding, {Philip Yu An} and Chen, {C. H.}",

year = "2002",

doi = "10.1007/s003800200003",

language = "English (US)",

volume = "16",

pages = "99--104",

journal = "Heart and Vessels",

issn = "0910-8327",

publisher = "Springer Japan",

number = "3",

}

TY - JOUR

T1 - Assessment of left ventricular end-systolic elastance from aortic pressure-left ventricular volume relations

AU - Lee, Wen Shin

AU - Nakayama, Masaru

AU - Huang, Wen Pin

AU - Chiou, Kuan Rau

AU - Wu, Chih Cheng

AU - Nevo, Erez

AU - Fetics, Barry

AU - Kass, David A.

AU - Ding, Philip Yu An

AU - Chen, C. H.

PY - 2002

Y1 - 2002

N2 - The left ventricular (LV) end-systolic pressure-volume relation (ESPVR) is a load-insensitive method for evaluating LV contractility, which needs invasive measurement. Some noninvasive methods substitute peak aortic pressure (Ps) for end-systolic LV pressure by assuming there is no difference between these pressures. However, this assumption has not been directly validated. With conductance catheter and dual micromanometers, ESPVRs and the slope (EesLV) were constructed from simultaneous LV pressures (LVP) and volumes, aortic pressures (AOP) and LV volumes (EesAO), and Ps and LV end-ejection volumes (VEE) (EesPP-EEV) during preload reduction in 50 subjects. The ratio of steady-state Ps over VEE (Ps/VEE) was also checked. AOP and LVP displayed differences of 11 ± 6 and -30 ± 12 mmHg at the onset and end-ejection, respectively, and -2 ± 4 mmHg at end-systole. EesAO and EesLV were nearly identical: EesAO = 0.97 × EesLV + 0.05, r2 = 0.99. EesPP-EEV correlated with EesLV (EesPP-EEV = 0.57 × EesLV + 0.61, r2 = 0.46) but with much more scatter. Ps/VEE correlated worst with EesLV. Central AOP can be substituted for LVP to derive EesLV. Other estimation methods yield weaker and poor correlations to directly measured Ees.

AB - The left ventricular (LV) end-systolic pressure-volume relation (ESPVR) is a load-insensitive method for evaluating LV contractility, which needs invasive measurement. Some noninvasive methods substitute peak aortic pressure (Ps) for end-systolic LV pressure by assuming there is no difference between these pressures. However, this assumption has not been directly validated. With conductance catheter and dual micromanometers, ESPVRs and the slope (EesLV) were constructed from simultaneous LV pressures (LVP) and volumes, aortic pressures (AOP) and LV volumes (EesAO), and Ps and LV end-ejection volumes (VEE) (EesPP-EEV) during preload reduction in 50 subjects. The ratio of steady-state Ps over VEE (Ps/VEE) was also checked. AOP and LVP displayed differences of 11 ± 6 and -30 ± 12 mmHg at the onset and end-ejection, respectively, and -2 ± 4 mmHg at end-systole. EesAO and EesLV were nearly identical: EesAO = 0.97 × EesLV + 0.05, r2 = 0.99. EesPP-EEV correlated with EesLV (EesPP-EEV = 0.57 × EesLV + 0.61, r2 = 0.46) but with much more scatter. Ps/VEE correlated worst with EesLV. Central AOP can be substituted for LVP to derive EesLV. Other estimation methods yield weaker and poor correlations to directly measured Ees.

KW - Central aortic pressure

KW - End-systolic pressure-volume relationship

KW - Hemodynamics

KW - Left ventricular function

UR - http://www.scopus.com/inward/record.url?scp=18344392246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344392246&partnerID=8YFLogxK

U2 - 10.1007/s003800200003

DO - 10.1007/s003800200003

M3 - Article

C2 - 12027239

AN - SCOPUS:18344392246

SN - 0910-8327

VL - 16

SP - 99

EP - 104

JO - Heart and Vessels

JF - Heart and Vessels

IS - 3

ER -

Assessment of left ventricular end-systolic elastance from aortic pressure-left ventricular volume relations

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this