Assessment of gastric emptying using a low fat meal: Establishment of international control values

Gervais Tougas, Ervin Y. Eaker, Thomas L. Abell, Hasse Abrahamsson, Michel Boivin, Jiande Chen, Michael P. Hocking, Eamonn M M Quigley, Kenneth L. Koch, Aaron Zev Tokayer, Vincenzo Stanghellini, Ying Chen, Jan D. Huizinga, Johan Rydén, Ivan Bourgeois M.b.a, Richard W. McCallum

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The diagnosis of gastroparesis implies delayed gastric emptying. The diagnostic gold standard is scintigraphy, but techniques and measured endpoints vary widely among institutions. In this study, a simplified scintigraphic measurement of gastric emptying was compared to conventional gastric scintigraphic techniques and normal gastric emptying values defined in healthy subjects. METHODS: In 123 volunteers (aged 19-73 yr, 60 women and 63 men) from 11 centers, scintigraphy was used to assess gastric emptying of a 99Tc-labeled low fat meal (egg substitute) and percent intragastric residual contents 60, 120, and 240 min after completion of the meal. In 42 subjects, additional measurements were taken every 10 min for 1 h. In 20 subjects, gastric emptying of a 99Tc-labeled liver meal was compared with that of the 99Tc-labeled low fat meal. RESULTS: Median values (95th percentile) for percent gastric retention at 60, 120, and 240 min were 69% (90%), 24% (60%) and 1.2% (10%) respectively. A power exponential model yielded similar emptying curves and estimated T50 when using images only taken at 1, 2 and 4 h, or with imaging taken every 10 min. Gastric emptying was initially more rapid in men but was comparable in men and women at 4 h; it was faster in older subjects (p <0.05) but was independent of body mass index. CONCLUSIONS: This multicenter study provides gastric emptying values in healthy subjects based on data obtained using a large sample size and consistent meal and methodology. Gastric retention of >10% at 4 h is indicative of delayed emptying, a value comparable to those provided by more intensive scanning approaches. Gastric emptying of a low fat meal is initially faster in men but is comparable in women at 4 h; it is also faster in older individuals but is independent of body mass. (C) 2000 Am. Coll. of Gastroenterology.

Original languageEnglish (US)
Pages (from-to)1456-1462
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume95
Issue number6
DOIs
StatePublished - Jun 2000
Externally publishedYes

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Gastric Emptying
Meals
Fats
Radionuclide Imaging
Stomach
Gastroparesis
Gastroenterology
Ovum
Volunteers
Healthy Volunteers
Liver

ASJC Scopus subject areas

  • Gastroenterology

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Assessment of gastric emptying using a low fat meal : Establishment of international control values. / Tougas, Gervais; Eaker, Ervin Y.; Abell, Thomas L.; Abrahamsson, Hasse; Boivin, Michel; Chen, Jiande; Hocking, Michael P.; Quigley, Eamonn M M; Koch, Kenneth L.; Tokayer, Aaron Zev; Stanghellini, Vincenzo; Chen, Ying; Huizinga, Jan D.; Rydén, Johan; Bourgeois M.b.a, Ivan; McCallum, Richard W.

In: American Journal of Gastroenterology, Vol. 95, No. 6, 06.2000, p. 1456-1462.

Research output: Contribution to journalArticle

Tougas, G, Eaker, EY, Abell, TL, Abrahamsson, H, Boivin, M, Chen, J, Hocking, MP, Quigley, EMM, Koch, KL, Tokayer, AZ, Stanghellini, V, Chen, Y, Huizinga, JD, Rydén, J, Bourgeois M.b.a, I & McCallum, RW 2000, 'Assessment of gastric emptying using a low fat meal: Establishment of international control values', American Journal of Gastroenterology, vol. 95, no. 6, pp. 1456-1462. https://doi.org/10.1016/S0002-9270(00)00868-6
Tougas, Gervais ; Eaker, Ervin Y. ; Abell, Thomas L. ; Abrahamsson, Hasse ; Boivin, Michel ; Chen, Jiande ; Hocking, Michael P. ; Quigley, Eamonn M M ; Koch, Kenneth L. ; Tokayer, Aaron Zev ; Stanghellini, Vincenzo ; Chen, Ying ; Huizinga, Jan D. ; Rydén, Johan ; Bourgeois M.b.a, Ivan ; McCallum, Richard W. / Assessment of gastric emptying using a low fat meal : Establishment of international control values. In: American Journal of Gastroenterology. 2000 ; Vol. 95, No. 6. pp. 1456-1462.
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abstract = "OBJECTIVE: The diagnosis of gastroparesis implies delayed gastric emptying. The diagnostic gold standard is scintigraphy, but techniques and measured endpoints vary widely among institutions. In this study, a simplified scintigraphic measurement of gastric emptying was compared to conventional gastric scintigraphic techniques and normal gastric emptying values defined in healthy subjects. METHODS: In 123 volunteers (aged 19-73 yr, 60 women and 63 men) from 11 centers, scintigraphy was used to assess gastric emptying of a 99Tc-labeled low fat meal (egg substitute) and percent intragastric residual contents 60, 120, and 240 min after completion of the meal. In 42 subjects, additional measurements were taken every 10 min for 1 h. In 20 subjects, gastric emptying of a 99Tc-labeled liver meal was compared with that of the 99Tc-labeled low fat meal. RESULTS: Median values (95th percentile) for percent gastric retention at 60, 120, and 240 min were 69{\%} (90{\%}), 24{\%} (60{\%}) and 1.2{\%} (10{\%}) respectively. A power exponential model yielded similar emptying curves and estimated T50 when using images only taken at 1, 2 and 4 h, or with imaging taken every 10 min. Gastric emptying was initially more rapid in men but was comparable in men and women at 4 h; it was faster in older subjects (p <0.05) but was independent of body mass index. CONCLUSIONS: This multicenter study provides gastric emptying values in healthy subjects based on data obtained using a large sample size and consistent meal and methodology. Gastric retention of >10{\%} at 4 h is indicative of delayed emptying, a value comparable to those provided by more intensive scanning approaches. Gastric emptying of a low fat meal is initially faster in men but is comparable in women at 4 h; it is also faster in older individuals but is independent of body mass. (C) 2000 Am. Coll. of Gastroenterology.",
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T1 - Assessment of gastric emptying using a low fat meal

T2 - Establishment of international control values

AU - Tougas, Gervais

AU - Eaker, Ervin Y.

AU - Abell, Thomas L.

AU - Abrahamsson, Hasse

AU - Boivin, Michel

AU - Chen, Jiande

AU - Hocking, Michael P.

AU - Quigley, Eamonn M M

AU - Koch, Kenneth L.

AU - Tokayer, Aaron Zev

AU - Stanghellini, Vincenzo

AU - Chen, Ying

AU - Huizinga, Jan D.

AU - Rydén, Johan

AU - Bourgeois M.b.a, Ivan

AU - McCallum, Richard W.

PY - 2000/6

Y1 - 2000/6

N2 - OBJECTIVE: The diagnosis of gastroparesis implies delayed gastric emptying. The diagnostic gold standard is scintigraphy, but techniques and measured endpoints vary widely among institutions. In this study, a simplified scintigraphic measurement of gastric emptying was compared to conventional gastric scintigraphic techniques and normal gastric emptying values defined in healthy subjects. METHODS: In 123 volunteers (aged 19-73 yr, 60 women and 63 men) from 11 centers, scintigraphy was used to assess gastric emptying of a 99Tc-labeled low fat meal (egg substitute) and percent intragastric residual contents 60, 120, and 240 min after completion of the meal. In 42 subjects, additional measurements were taken every 10 min for 1 h. In 20 subjects, gastric emptying of a 99Tc-labeled liver meal was compared with that of the 99Tc-labeled low fat meal. RESULTS: Median values (95th percentile) for percent gastric retention at 60, 120, and 240 min were 69% (90%), 24% (60%) and 1.2% (10%) respectively. A power exponential model yielded similar emptying curves and estimated T50 when using images only taken at 1, 2 and 4 h, or with imaging taken every 10 min. Gastric emptying was initially more rapid in men but was comparable in men and women at 4 h; it was faster in older subjects (p <0.05) but was independent of body mass index. CONCLUSIONS: This multicenter study provides gastric emptying values in healthy subjects based on data obtained using a large sample size and consistent meal and methodology. Gastric retention of >10% at 4 h is indicative of delayed emptying, a value comparable to those provided by more intensive scanning approaches. Gastric emptying of a low fat meal is initially faster in men but is comparable in women at 4 h; it is also faster in older individuals but is independent of body mass. (C) 2000 Am. Coll. of Gastroenterology.

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