TY - JOUR
T1 - Assessment of environmental enteropathy in the MAL-ED cohort study
T2 - Theoretical and analytic framework
AU - Kosek, Margaret
AU - Guerrant, Richard L.
AU - Kang, Gagandeep
AU - Bhutta, Zulfiqar
AU - Yori, Pablo Penãtaro
AU - Gratz, Jean
AU - Gottlieb, Michael
AU - Lang, Dennis
AU - Lee, Gwenyth
AU - Haque, Rashidul
AU - Mason, Carl J.
AU - Ahmed, Tahmeed
AU - Lima, Aldo
AU - Petri, William A.
AU - Houpt, Eric
AU - Olortegui, Maribel Paredes
AU - Seidman, Jessica C.
AU - Mduma, Estomih
AU - Samie, Amidou
AU - Babji, Sudhir
N1 - Publisher Copyright:
© 2014 The Author.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Individuals in the developing world live in conditions of intense exposure to enteric pathogens due to suboptimal water and sanitation. These environmental conditions lead to alterations in intestinal structure, function, and local and systemic immune activation that are collectively referred to as environmental enteropathy (EE). This condition, although poorly defined, is likely to be exacerbated by undernutrition as well as being responsible for permanent growth deficits acquired in early childhood, vaccine failure, and loss of human potential. This article addresses the underlying theoretical and analytical frameworks informing the methodology proposed by the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study to define and quantify the burden of disease caused by EE within a multisite cohort. Additionally, we will discuss efforts to improve, standardize, and harmonize laboratory practices within the MAL-ED Network. These efforts will address current limitations in the understanding of EE and its burden on children in the developing world.
AB - Individuals in the developing world live in conditions of intense exposure to enteric pathogens due to suboptimal water and sanitation. These environmental conditions lead to alterations in intestinal structure, function, and local and systemic immune activation that are collectively referred to as environmental enteropathy (EE). This condition, although poorly defined, is likely to be exacerbated by undernutrition as well as being responsible for permanent growth deficits acquired in early childhood, vaccine failure, and loss of human potential. This article addresses the underlying theoretical and analytical frameworks informing the methodology proposed by the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study to define and quantify the burden of disease caused by EE within a multisite cohort. Additionally, we will discuss efforts to improve, standardize, and harmonize laboratory practices within the MAL-ED Network. These efforts will address current limitations in the understanding of EE and its burden on children in the developing world.
KW - environmental enteropathy
KW - infant growth failure
KW - intestinal infections
KW - lactulose mannitol test
KW - tropical enteropathy
UR - http://www.scopus.com/inward/record.url?scp=84913584581&partnerID=8YFLogxK
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U2 - 10.1093/cid/ciu457
DO - 10.1093/cid/ciu457
M3 - Article
C2 - 25305293
AN - SCOPUS:84913584581
SN - 1058-4838
VL - 59
SP - S239-S247
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
ER -