Assessment of Endothelial Dysfunction With Flow-Mediated Dilatation in Myeloproliferative Disorders

Abdulkerim Yildiz, Melike Güryildirim, Mehmet Sezgin Pepeler, Merve Yazol, Suna Özhan Oktar, Kadir Acar

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Thrombosis is the most important cardiovascular complication of classical myeloproliferative disorders (MPDs). Endothelial dysfunction (ED) is known to play a major role in the mechanism of thrombophilia in MPDs. Methods: Endothelial dysfunction and its associations with other parameters were investigated. A total of 18 patients with polycythemia vera (PV), 24 with essential thrombocytosis (ET), 7 with primary myelofibrosis (PMF), and 30 healthy patients as a control group were included in the study. To assess the ED, flow-mediated dilatation (FMD) measurements were used. Results: The FMD (%) result showing ED was determined as 9.9 (0.0-21.6) in the patients with PV, 7.3 (0.0-30.5) in patients with ET, 7.5 (0.0-18.0) in patients with PMF, and 13.9 (6.2-26.7) in the control group. The FMD (%) was markedly impaired in all patients with MPD compared to the control patients (7.8 [0.0-30.5] vs 13.9 [6.15-26.8], P =.02). According to the disease subtypes, FMD (%) was significantly lower in the ET group than in the control group (P =.01). Conclusion: Endothelial function was assessed in patients with MPD having FMD and was determined to demonstrate ED. Lower FMD was associated with older age, leukocytosis, thrombocytosis, and thrombosis history.

Original languageEnglish (US)
Pages (from-to)1102-1108
Number of pages7
JournalClinical and Applied Thrombosis/Hemostasis
Volume24
Issue number7
DOIs
StatePublished - Oct 1 2018
Externally publishedYes

Keywords

  • endothelial dysfunction
  • flow-mediated dilatation
  • myeloproliferative disorders
  • risk factors
  • thrombosis

ASJC Scopus subject areas

  • Hematology

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