Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Henry N. Wagner; H. Donald Burns; Robert F. Dannals; Dean F. Wong; Bengt Langström; Timothy Duelfer; J. James Frost; Hayden T. Ravert; Jonathan M. Links; Shelley B. Rosenbloom; Scott E. Lukas; Alfred V. Kramer; Michael J. Kuhar

doi:10.1002/ana.410150715

Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Henry N. Wagner, H. Donald Burns, Robert F. Dannals, Dean F. Wong, Bengt Langström, Timothy Duelfer, J. James Frost, Hayden T. Ravert, Jonathan M. Links, Shelley B. Rosenbloom, Scott E. Lukas, Alfred V. Kramer, Michael J. Kuhar

School of Medicine

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

Original language	English (US)
Pages (from-to)	79-84
Number of pages	6
Journal	Annals of neurology
Volume	15
Issue number	1 S
DOIs	https://doi.org/10.1002/ana.410150715
State	Published - 1984

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Wagner, H. N., Burns, H. D., Dannals, R. F., Wong, D. F., Langström, B., Duelfer, T., Frost, J. J., Ravert, H. T., Links, J. M., Rosenbloom, S. B., Lukas, S. E., Kramer, A. V., & Kuhar, M. J. (1984). Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone. Annals of neurology, 15(1 S), 79-84. https://doi.org/10.1002/ana.410150715

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abstract = "We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.",

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year = "1984",

doi = "10.1002/ana.410150715",

language = "English (US)",

volume = "15",

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T1 - Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

AU - Wagner, Henry N.

AU - Burns, H. Donald

AU - Dannals, Robert F.

AU - Wong, Dean F.

AU - Langström, Bengt

AU - Duelfer, Timothy

AU - Frost, J. James

AU - Ravert, Hayden T.

AU - Links, Jonathan M.

AU - Rosenbloom, Shelley B.

AU - Lukas, Scott E.

AU - Kramer, Alfred V.

AU - Kuhar, Michael J.

PY - 1984

Y1 - 1984

N2 - We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

AB - We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

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ER -

Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Abstract

ASJC Scopus subject areas

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