Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Henry N. Wagner, H. Donald Burns, Robert F. Dannals, Dean Foster Wong, Bengt Langström, Timothy Duelfer, J. James Frost, Hayden T Ravert, Jonathan M. Links, Shelley B. Rosenbloom, Scott E. Lukas, Alfred V. Kramer, Michael J. Kuhar

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalAnnals of neurology
Volume15
Issue number1 S
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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