Assessment of dezocine for morphine-like subjective effects and miosis

Donald R. Jasinski, Kenzie L. Preston

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Dezocine is an analgesic soon to be marketed in the United States. In this study we examined the abuse potential of dezocine. Subjective and miotic effects of single subcutaneous doses of dezocine, morphine, and placebo were assessed under double-blind conditions in 10 adult male nondependent drug abusers. Dezocine and morphine were equipotent in inducing a constellation of effects typical of opioid agonists, including miosis and increases in opioid signs and symptoms, liking, and euphoria. Both drugs were consistently identified by subjects as being "dope" (opiates). Thus the profile of effects of single doses of dezocine indicate that the drug has the potential to be abused However, the agonist-antagonist activities of dezocine demonstrated by others suggest that its abuse potential is less than that of morphine.

Original languageEnglish (US)
Pages (from-to)544-548
Number of pages5
JournalClinical pharmacology and therapeutics
Issue number5
StatePublished - Nov 1985

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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