Assessment of cardiac involvement in myotonic muscular dystrophy by T1 mapping on magnetic resonance imaging

Evrim B. Turkbey, Neville Gai, Joao Lima, Rob J. Van Der Geest, Kathryn Rae Wagner, Gordon F. Tomaselli, David A. Bluemke, Saman Nazarian

Research output: Contribution to journalArticle

Abstract

Background: Patients with myotonic muscular dystrophy (DM) are at risk for atrioventricular block and left ventricular (LV) dysfunction. Noninvasive detection of diffuse myocardial fibrosis may improve disease management in this population. Objective: To define functional and postcontrast myocardial T1 time cardiac magnetic resonance characteristics in patients with DM. Methods: Thirty-three patients with DM (24 with type 1 and 9 with type 2) and 13 healthy volunteers underwent cardiac magnetic resonance for the assessment of LV indices and the evaluation of diffuse myocardial fibrosis by T1 mapping. The association of myocardial T1 time with electrocardiogram abnormalities and LV indices was examined among patients with DM. Results: Patients with DM had lower end-diastolic volume index (68.9 mL/m2 vs 60.3 mL/m2; P =.045) and cardiac index (2.7 L/min/m2 vs 2.33 L/min/m2; P =.005) and shorter myocardial T1 time (394.5 ms vs 441.4 ms; P 2; P =.006), LV end-diastolic volume index (1.3 ms longer per mL/m2; P =.026), filtered QRS duration (1.2 ms longer per unit; P =.005), and low-amplitude (

Original languageEnglish (US)
Pages (from-to)1691-1697
Number of pages7
JournalHeart Rhythm
Volume9
Issue number10
DOIs
StatePublished - Oct 2012

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Myotonic Dystrophy
Muscular Dystrophies
Magnetic Resonance Imaging
Fibrosis
Magnetic Resonance Spectroscopy
Atrioventricular Block
Left Ventricular Dysfunction
Disease Management
Stroke Volume
Healthy Volunteers
Electrocardiography
Population

Keywords

  • MRI
  • Myotonic muscular dystrophy
  • T1 mapping
  • Ventricular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Assessment of cardiac involvement in myotonic muscular dystrophy by T1 mapping on magnetic resonance imaging. / Turkbey, Evrim B.; Gai, Neville; Lima, Joao; Van Der Geest, Rob J.; Wagner, Kathryn Rae; Tomaselli, Gordon F.; Bluemke, David A.; Nazarian, Saman.

In: Heart Rhythm, Vol. 9, No. 10, 10.2012, p. 1691-1697.

Research output: Contribution to journalArticle

Turkbey, EB, Gai, N, Lima, J, Van Der Geest, RJ, Wagner, KR, Tomaselli, GF, Bluemke, DA & Nazarian, S 2012, 'Assessment of cardiac involvement in myotonic muscular dystrophy by T1 mapping on magnetic resonance imaging', Heart Rhythm, vol. 9, no. 10, pp. 1691-1697. https://doi.org/10.1016/j.hrthm.2012.06.032
Turkbey, Evrim B. ; Gai, Neville ; Lima, Joao ; Van Der Geest, Rob J. ; Wagner, Kathryn Rae ; Tomaselli, Gordon F. ; Bluemke, David A. ; Nazarian, Saman. / Assessment of cardiac involvement in myotonic muscular dystrophy by T1 mapping on magnetic resonance imaging. In: Heart Rhythm. 2012 ; Vol. 9, No. 10. pp. 1691-1697.
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AU - Lima, Joao

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AU - Wagner, Kathryn Rae

AU - Tomaselli, Gordon F.

AU - Bluemke, David A.

AU - Nazarian, Saman

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