Abstract
This study describes assessment of brain muscarinic acetylcholinergic receptors in living mice using a single-crystal radiation detection system, the high-affinity antagonist [125I]-4-iododexetimide, and the inactive enantiomer [125I]-4-iodolevetimide. Kinetics of radioligand binding, as well as perturbation by atropine displacement, can be determined using this simple probe technique.
Original language | English (US) |
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Pages (from-to) | 1441-1443 |
Number of pages | 3 |
Journal | Neuropharmacology |
Volume | 32 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1993 |
Keywords
- 4-iododexetimide
- 4-iodolevetimide
- muscarinic acetylcholinergic receptor
- radioiodine
- single photon detection system
ASJC Scopus subject areas
- Pharmacology
- Cellular and Molecular Neuroscience