Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis

J. Philip Saul, Yutaka Arai, Ronald D Berger, Leonard S. Lilly, Wilson S. Colucci, Richard J. Cohen

Research output: Contribution to journalArticle

Abstract

Neurohumoral modulation of cardiovascular function is an important component of the hemodynamic alterations in patients with chronic congestive heart failure (CHF). Analysis of heart rate (HR) variability is a noninvasive means of investigating the autonomic control of the heart. The variability of HR and respiratory signals, both derived from ambulatory electrocardiographic recordings, were analyzed with power spectral analysis to evaluate autonomic control in 25 patients with chronic stable CHF (class III or IV) and 21 normal control subjects. In the patients with CHF, HR spectral power was markedly reduced (p <0.0001) at all frequencies examined (0.01 to 1.0 Hz, period 1 to 100 seconds) and virtually absent at frequencies >0.04 Hz. Heart rate fluctuations at very low frequencies (0.01 to 0.04 Hz) less effectively differentiated CHF patients from control subjects, due to discrete (about 65 seconds, 0.015 Hz) oscillation in HR, which was associated with a similar pattern in respiratory activity in many of the patients with CHF. These findings demonstrate a marked derangement of HR modulation in patients with severe CHF. The frequency characteristics of HR fluctuations in these patients are consistent with abnormal baroreflex responsiveness to physiologic stimuli, and suggest that there is diminished vagal, but relatively preserved sympathetic, modulation of HR.

Original languageEnglish (US)
Pages (from-to)1292-1299
Number of pages8
JournalThe American Journal of Cardiology
Volume61
Issue number15
DOIs
StatePublished - Jun 1 1988
Externally publishedYes

Fingerprint

Heart Failure
Heart Rate
Baroreflex
Hemodynamics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis. / Saul, J. Philip; Arai, Yutaka; Berger, Ronald D; Lilly, Leonard S.; Colucci, Wilson S.; Cohen, Richard J.

In: The American Journal of Cardiology, Vol. 61, No. 15, 01.06.1988, p. 1292-1299.

Research output: Contribution to journalArticle

Saul, J. Philip ; Arai, Yutaka ; Berger, Ronald D ; Lilly, Leonard S. ; Colucci, Wilson S. ; Cohen, Richard J. / Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis. In: The American Journal of Cardiology. 1988 ; Vol. 61, No. 15. pp. 1292-1299.
@article{5d13dd4d67534a6891fbcc368f43f6de,
title = "Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis",
abstract = "Neurohumoral modulation of cardiovascular function is an important component of the hemodynamic alterations in patients with chronic congestive heart failure (CHF). Analysis of heart rate (HR) variability is a noninvasive means of investigating the autonomic control of the heart. The variability of HR and respiratory signals, both derived from ambulatory electrocardiographic recordings, were analyzed with power spectral analysis to evaluate autonomic control in 25 patients with chronic stable CHF (class III or IV) and 21 normal control subjects. In the patients with CHF, HR spectral power was markedly reduced (p <0.0001) at all frequencies examined (0.01 to 1.0 Hz, period 1 to 100 seconds) and virtually absent at frequencies >0.04 Hz. Heart rate fluctuations at very low frequencies (0.01 to 0.04 Hz) less effectively differentiated CHF patients from control subjects, due to discrete (about 65 seconds, 0.015 Hz) oscillation in HR, which was associated with a similar pattern in respiratory activity in many of the patients with CHF. These findings demonstrate a marked derangement of HR modulation in patients with severe CHF. The frequency characteristics of HR fluctuations in these patients are consistent with abnormal baroreflex responsiveness to physiologic stimuli, and suggest that there is diminished vagal, but relatively preserved sympathetic, modulation of HR.",
author = "Saul, {J. Philip} and Yutaka Arai and Berger, {Ronald D} and Lilly, {Leonard S.} and Colucci, {Wilson S.} and Cohen, {Richard J.}",
year = "1988",
month = "6",
day = "1",
doi = "10.1016/0002-9149(88)91172-1",
language = "English (US)",
volume = "61",
pages = "1292--1299",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "15",

}

TY - JOUR

T1 - Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis

AU - Saul, J. Philip

AU - Arai, Yutaka

AU - Berger, Ronald D

AU - Lilly, Leonard S.

AU - Colucci, Wilson S.

AU - Cohen, Richard J.

PY - 1988/6/1

Y1 - 1988/6/1

N2 - Neurohumoral modulation of cardiovascular function is an important component of the hemodynamic alterations in patients with chronic congestive heart failure (CHF). Analysis of heart rate (HR) variability is a noninvasive means of investigating the autonomic control of the heart. The variability of HR and respiratory signals, both derived from ambulatory electrocardiographic recordings, were analyzed with power spectral analysis to evaluate autonomic control in 25 patients with chronic stable CHF (class III or IV) and 21 normal control subjects. In the patients with CHF, HR spectral power was markedly reduced (p <0.0001) at all frequencies examined (0.01 to 1.0 Hz, period 1 to 100 seconds) and virtually absent at frequencies >0.04 Hz. Heart rate fluctuations at very low frequencies (0.01 to 0.04 Hz) less effectively differentiated CHF patients from control subjects, due to discrete (about 65 seconds, 0.015 Hz) oscillation in HR, which was associated with a similar pattern in respiratory activity in many of the patients with CHF. These findings demonstrate a marked derangement of HR modulation in patients with severe CHF. The frequency characteristics of HR fluctuations in these patients are consistent with abnormal baroreflex responsiveness to physiologic stimuli, and suggest that there is diminished vagal, but relatively preserved sympathetic, modulation of HR.

AB - Neurohumoral modulation of cardiovascular function is an important component of the hemodynamic alterations in patients with chronic congestive heart failure (CHF). Analysis of heart rate (HR) variability is a noninvasive means of investigating the autonomic control of the heart. The variability of HR and respiratory signals, both derived from ambulatory electrocardiographic recordings, were analyzed with power spectral analysis to evaluate autonomic control in 25 patients with chronic stable CHF (class III or IV) and 21 normal control subjects. In the patients with CHF, HR spectral power was markedly reduced (p <0.0001) at all frequencies examined (0.01 to 1.0 Hz, period 1 to 100 seconds) and virtually absent at frequencies >0.04 Hz. Heart rate fluctuations at very low frequencies (0.01 to 0.04 Hz) less effectively differentiated CHF patients from control subjects, due to discrete (about 65 seconds, 0.015 Hz) oscillation in HR, which was associated with a similar pattern in respiratory activity in many of the patients with CHF. These findings demonstrate a marked derangement of HR modulation in patients with severe CHF. The frequency characteristics of HR fluctuations in these patients are consistent with abnormal baroreflex responsiveness to physiologic stimuli, and suggest that there is diminished vagal, but relatively preserved sympathetic, modulation of HR.

UR - http://www.scopus.com/inward/record.url?scp=0023910101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023910101&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(88)91172-1

DO - 10.1016/0002-9149(88)91172-1

M3 - Article

C2 - 3376889

AN - SCOPUS:0023910101

VL - 61

SP - 1292

EP - 1299

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 15

ER -