Assessment of anovulation in eumenorrheic women: Comparison of ovulation detection algorithms

Kristine E. Lynch, Sunni L. Mumford, Karen C. Schliep, Brian W. Whitcomb, Shvetha M. Zarek, Anna Z. Pollack, Elizabeth R. Bertone-Johnson, Michelle Danaher, Jean Wactawski-Wende, Audrey J. Gaskins, Enrique F. Schisterman

Research output: Contribution to journalArticle

Abstract

Objective To compare previously used algorithms to identify anovulatory menstrual cycles in women self-reporting regular menses. Design Prospective cohort study. Setting Western New York. Patient(s) Two hundred fifty-nine healthy, regularly menstruating women followed for one (n = 9) or two (n = 250) menstrual cycles (2005-2007). Intervention(s) None. Main Outcome Measure(s) Prevalence of sporadic anovulatory cycles identified using 11 previously defined algorithms that use E2, P, and LH concentrations. Result(s) Algorithms based on serum LH, E2, and P levels detected a prevalence of anovulation across the study period of 5.5%-12.8% (concordant classification for 91.7%-97.4% of cycles). The prevalence of anovulatory cycles varied from 3.4% to 18.6% using algorithms based on urinary LH alone or with the primary E2 metabolite, estrone-3-glucuronide, levels. Conclusion(s) The prevalence of anovulatory cycles among healthy women varied by algorithm. Mid-cycle LH surge urine-based algorithms used in over-the-counter fertility monitors tended to classify a higher proportion of anovulatory cycles compared with luteal-phase P serum-based algorithms. Our study demonstrates that algorithms based on the LH surge, or in conjunction with estrone-3-glucuronide, potentially estimate a higher percentage of anovulatory episodes. Addition of measurements of postovulatory serum P or urine pregnanediol may aid in detecting ovulation.

Original languageEnglish (US)
JournalFertility and Sterility
Volume102
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • estradiol
  • luteinizing hormone
  • menstrual cycles
  • Ovulation
  • progesterone

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

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    Lynch, K. E., Mumford, S. L., Schliep, K. C., Whitcomb, B. W., Zarek, S. M., Pollack, A. Z., Bertone-Johnson, E. R., Danaher, M., Wactawski-Wende, J., Gaskins, A. J., & Schisterman, E. F. (2014). Assessment of anovulation in eumenorrheic women: Comparison of ovulation detection algorithms. Fertility and Sterility, 102(2). https://doi.org/10.1016/j.fertnstert.2014.04.035