Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand

Lakkana Thaikruea, Niwes Nantachit, Nipapan Leetrakool, Ladda Fongsatitkul, Prakai Sompan, Andrew Heaton, Kenrad Edwin Nelson

Research output: Contribution to journalArticle

Abstract

A self-deferral form has been used to screen Chiang Mai University Hospital blood donors and was improved in 2005. It has never been evaluated. The study aimed to assess the self-deferral form procedures in detecting infected donors. Sera from 5,083 donors, who passed the self-deferral screening form, were tested with the routine immuno-assays (serology) for HIV 1 and 2 antibodies, P24 antigen, HCV antibodies, HBV surface antigen, and syphilis. Antibody negative sera were also tested individually with the the Procleix Ultrio Assay for HIV-1 DNA, HCV RNA, and HBV DNA. The donors who had discrepant results between serology and NAT were evaluated with additional tests, including a more sensitive Alternative Nucleic Acid Test, AntiBcore IgM, AntiBcore IgG, HBsAg and Anti HBs. Among 5,083 donors, 331 (6.5%) had at least one positive marker. In multiple logistic regression analysis, the statistically significant factors (adjusted odds ratio and 95% CI) for infection were age 30 years or below [1.45 (1.03, 2.03)], male gender [2.73 (1.64, 4.56)], primary school or lower education [1.56 (1.09, 2.23)], first-time donation [1.82 (1.25, 2.67)], and frequent donation [0.80 (0.70, 0.92)]. The safest donors were females, older than 30 years, with an education more than primary school, and frequent donation. Because of missing responses to some sensitive questions there remains a need for further improvement of the self-deferral form.

Original languageEnglish (US)
Pages (from-to)906-912
Number of pages7
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Volume39
Issue number5
StatePublished - Sep 2008

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Thailand
Blood Donors
Tissue Donors
Serology
HIV-1
Education
HIV-2
Hepatitis C Antibodies
Antibodies
DNA
Syphilis
Surface Antigens
Hepatitis B Surface Antigens
Serum
Nucleic Acids
Immunoglobulin M
Logistic Models
Odds Ratio
Regression Analysis
RNA

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health

Cite this

Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand. / Thaikruea, Lakkana; Nantachit, Niwes; Leetrakool, Nipapan; Fongsatitkul, Ladda; Sompan, Prakai; Heaton, Andrew; Nelson, Kenrad Edwin.

In: Southeast Asian Journal of Tropical Medicine and Public Health, Vol. 39, No. 5, 09.2008, p. 906-912.

Research output: Contribution to journalArticle

Thaikruea, L, Nantachit, N, Leetrakool, N, Fongsatitkul, L, Sompan, P, Heaton, A & Nelson, KE 2008, 'Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand', Southeast Asian Journal of Tropical Medicine and Public Health, vol. 39, no. 5, pp. 906-912.
Thaikruea, Lakkana ; Nantachit, Niwes ; Leetrakool, Nipapan ; Fongsatitkul, Ladda ; Sompan, Prakai ; Heaton, Andrew ; Nelson, Kenrad Edwin. / Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand. In: Southeast Asian Journal of Tropical Medicine and Public Health. 2008 ; Vol. 39, No. 5. pp. 906-912.
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