Assessment and detection of depression in patients with coronary artery disease: validation of the Persian version of the PHQ-9

Leila Gholizadeh, Nazila Shahmansouri, Mehrdad Heydari, Patricia M Davidson

Research output: Contribution to journalArticle


Background: Depression is a common comorbidity in patients with coronary artery disease (CAD), which often remains undetected and untreated. Objective: This study aimed to examine the psychometric properties of the Depression Module of the Patient Health Questionnaire (PHQ-9) on a sample of cardiac patients in Iran. Method: The Persian version of the PHQ-9 was developed and administered to 150 patients with CAD, admitted to a tertiary hospital in Tehran, Iran. The major depression module of the International Neuropsychiatric Interview (MINI) was used as the gold standard for the diagnosis of depression. Results: The Persian PHQ-9 demonstrated acceptable internal consistency, with Cronbach’s alpha coefficient of 0.80. The optimal cut-off score of ≥7 showed a sensitivity of 76, specificity of 78, and the area under curve of 0.82. Conclusion: The Persian PHQ-9 has acceptable psychometric properties to screen for and detect a current depressive episode in patients with CAD, with recommended cut-off score of ≥7.

Original languageEnglish (US)
JournalContemporary Nurse
Publication statusPublished - Jan 1 2019



  • coronary artery disease
  • depression
  • nursing
  • the PHQ-9
  • validation study

ASJC Scopus subject areas

  • Nursing(all)

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