Assessing tumor response after loco-regional liver cancer therapies: The role of 3D MRI

Julius Chapiro, Mingde Lin, Rafael Duran, Rüdiger E. Schernthaner, Jean François Geschwind

Research output: Contribution to journalReview articlepeer-review

Abstract

Assessing the tumor response of liver cancer lesions after intraarterial therapies is of major clinical interest. Over the last two decades, tumor response criteria have come a long way from purely size-based, anatomic methods such as the Response Evaluation Criteria in Solid Tumors towards more functional, enhancement- and diffusion-based parameters with a strong emphasis on MRI as the ultimate imaging modality. However, the relatively low reproducibility of those one- and 2D techniques (modified Response Evaluation Criteria in Solid Tumors and the European Association for the Study of the Liver criteria) provided the rationale for the development of new, 3D quantitative assessment techniques. This review will summarize and compare the existing methodologies used for 3D quantitative tumor analysis and provide an overview of the published clinical evidence for the benefits of 3D quantitative tumor response assessment techniques.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalExpert Review of Anticancer Therapy
Volume15
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • 3D
  • ADC
  • MRI
  • RECIST
  • intraarterial therapy
  • liver cancer
  • qEASL
  • quantitative imaging
  • tumor response

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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