Assessing the intestinal microbiota in the SHINE Trial

Ethan Gough, Andrew J. Prendergast, Kuda E. Mutasa, Rebecca J. Stoltzfus, Amee R. Manges

Research output: Contribution to journalReview article

Abstract

Advances in DNA sequencing technology now allow us to explore the dynamics and functions of the microbes that inhabit the human body, the microbiota. Recent studies involving experimental animal models suggest a role of the gut microbiota in growth. However, the specific changes in the human gut microbiota that contribute to growth remain unclear, and studies investigating the gut microbiota as a determinant of environmental enteric dysfunction (EED) and child stunting are lacking. In this article, we review the evidence for a link between the developing infant gut microbiota, infant feeding, EED, and stunting, and discuss the potential causal pathways relating these variables. We outline the analytic approaches we will use to investigate these relationships, by capitalizing on the longitudinal design and randomized interventions of the Sanitation Hygiene Infant Nutrition Efficacy trial in Zimbabwe.

Original languageEnglish (US)
Pages (from-to)S738-S744
JournalClinical Infectious Diseases
Volume61
DOIs
Publication statusPublished - Dec 15 2015
Externally publishedYes

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Keywords

  • environmental enteric dysfunction
  • infant
  • microbiota
  • stunting

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Gough, E., Prendergast, A. J., Mutasa, K. E., Stoltzfus, R. J., & Manges, A. R. (2015). Assessing the intestinal microbiota in the SHINE Trial. Clinical Infectious Diseases, 61, S738-S744. https://doi.org/10.1093/cid/civ850