Assessing the global threat from Zika virus

Justin T Lessler, Lelia H. Chaisson, Lauren M. Kucirka, Qifang Bi, Kyra Grantz, Henrik Salje, Andrea C. Carcelen, Cassandra T. Ott, Jeanne Sheffield, Neil M. Ferguson, Derek A.T. Cummings, C. Jessica E. Metcalf, Isabel Rodriguez-Barraquer

Research output: Contribution to journalReview article


First discovered in 1947, Zika virus (ZIKV) infection remained a little-known tropical disease until 2015, when its apparent association with a considerable increase in the incidence of microcephaly in Brazil raised alarms worldwide. There is limited information on the key factors that determine the extent of the global threat from ZIKV infection and resulting complications. Here, we review what is known about the epidemiology, natural history, and public health effects of ZIKV infection, the empirical basis for this knowledge, and the critical knowledge gaps that need to be filled.

Original languageEnglish (US)
Pages (from-to)aaf8160
Issue number6300
Publication statusPublished - Aug 12 2016


ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Lessler, J. T., Chaisson, L. H., Kucirka, L. M., Bi, Q., Grantz, K., Salje, H., ... Rodriguez-Barraquer, I. (2016). Assessing the global threat from Zika virus. Science, 353(6300), aaf8160.