Assessing the current role of platelet function testing

Eugene Braunwald, Dominick Angiolillo, Eric Bates, Peter B. Berger, Deepak Bhatt, Christopher P. Cannon, Mark I. Furman, Paul Gurbel, Alan D. Michelson, Eric Peterson, Stephen Wiviott

Research output: Contribution to journalArticlepeer-review

Abstract

In vitro platelet function tests are commonly applied in research and offer justification for using antiplatelet therapy. However, studies assessing the ability of standardized platelet function tests to predict patients' clinical response to aspirin or clopidogrel have generated contradictory results. At this time, there is no standardized definition for resistance to antiplatelet therapy, and the appropriate treatment of patients who are hyporesponsive to these agents is not known. Although such tests have a role in research, their place in guiding therapy remains to be established, and prospective trials are urgently needed. The ideal platelet function test for clinical practice would be rapid, easy-to-use, inexpensive, and reliable.

Original languageEnglish (US)
Pages (from-to)I10-I16
JournalClinical Cardiology
Volume31
Issue number3 SUUPL. 1
DOIs
StatePublished - Mar 2008

Keywords

  • Acute coronary syndromes <ischemic heart disease
  • Catheterization/diagnostic interventional <cardiac
  • Platelets
  • Thrombosis/hypercoagulable states

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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