Assessing neuroreceptor occupancy by continuous infusion of carbon-11 labeled radioligands

Pan Fu Kao, Stanley Kim, Henry N. Wagner, John R. Lever, Hayden T. Ravert, Robert F. Dannals

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In carbon-11 labeled radiotracer studies of neuroreceptors in the brain, a state of practical equilibrium, monitored with a simple dual-probe detector system, was achieved by injection of a bolus of tracer followed by a continuous infusion of the tracer. After investigating several different bolus-to-infusion activity ratios, we observed that a practical equilibrium state could be achieved with a slope of 0.02 ± 0.001 cps x kg/μCi/min for [11C]carfentanil studies in normal human beings. The usefulness of this approach to assess neuroreceptor occupancy was demonstrated in two cases.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalEuropean Journal of Nuclear Medicine
Issue number2
StatePublished - 1996


  • Carbon-11 radioligands
  • Continuous infusion
  • Dual-probe detector system
  • Equilibrium state

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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