Assessing cognitive improvement in people with down syndrome: Important considerations for drug-efficacy trials

Fabian Fernandez, Roger H. Reeves

Research output: Contribution to journalArticle

Abstract

Experimental research over just the past decade has raised the possibility that learning deficits connected to Down syndrome (DS) might be effectively managed by medication. In the current chapter, we touch on some of the work that paved the way for these advances and discuss the challenges associated with translating them. In particular, we highlight sources of phenotypic variability in the DS population that are likely to impact performance assessments. Throughout, suggestions are made on how to detect meaningful changes in cognitive– adaptive function in people with DS during drug treatment. The importance of within-subjects evaluation is emphasized.

Original languageEnglish (US)
Pages (from-to)335-380
Number of pages46
JournalHandbook of Experimental Pharmacology
Volume228
DOIs
StatePublished - Jan 1 2015

Keywords

  • Adaptive
  • Behavior
  • Clinical trial
  • Cognition
  • Down syndrome
  • Drug treatment
  • Intellectual disability

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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