Aspirin use in sturge-weber syndrome: Side effects and clinical outcomes

Eboni I. Lance, Aditya K. Sreenivasan, Theodore A Zabel, Eric H Kossoff, Anne Marie Spalding Comi

Research output: Contribution to journalArticle

Abstract

Sturge-Weber syndrome is a neurocutaneous disorder with skin, eye, and brain involvement. Prior series suggest about 50% of patients have seizures/neurodeterioration. Low-dose (3-5 mg/kg/d) aspirin use in this population is controversial. This study further addresses the side effects and outcomes of low-dose aspirin usage in Sturge-Weber syndrome. Fifty-eight subjects on aspirin with brain involvement were analyzed in a retrospective chart review. Charts were evaluated for brain involvement, age at first seizure, and side effects. Subjects' clinical stability was compared using neurologic scores. The majority of subjects had neurologic scores reflecting reasonable seizure control (91%), none or mild hemiparesis (57%), no vision impairment (71%), and none or mild cognitive impairment (80%). Forty-nine reported no significant side effects, and 9 reported either allergic reaction or minimal to significant bleeding on aspirin. This cohort's clinical experience adds significant support for low-dose aspirin use to optimize neurodevelopmental outcome in Sturge-Weber syndrome with minimal side effects.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalJournal of Child Neurology
Volume28
Issue number2
DOIs
StatePublished - Feb 2013

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Keywords

  • aspirin
  • neurocutaneous syndrome
  • Sturge-Weber syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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