Aspirin induced depression of renal function

The authors observed elevation of serum creatinine and blood urea nitrogen and decrease in creatinine clearance in patients taking anti-inflammatory doses independence. Moreover, the financially of 23 patients with systemic lupus erythematosus increases in serum creatinine ranged from 27 to 163 percent, and those in urea nitrogen from 42 to 270 percent. Sequential creatinine clearance studies, available in 11 of the 13 patients, demonstrated decreases up to 58 percent. Patients with aspirin-induced changes in renal function were more likely to have active renal disease (P=0.035) or hypocomplementemia (P=0.030). Four of 22 patients with rheumatoid arthritis and two of three normal volunteers also demonstrated biochemical changes. The rate of aspirin-induced alterations was significantly higher in systemic lupus erythematosus (P=0.007) than in rheumatoid arthritis. Aspirin, and other nonsteroidal anti-inflammatory agents, can have a major reversible effect on renal function that may influence the interpretation of clinical data.