Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer

A PLCO Study

F. M. Shebl, L. C. Sakoda, A. Black, J. Koshiol, G. L. Andriole, R. Grubb, T. R. Church, D. Chia, C. Zhou, L. W. Chu, W. Y. Huang, U. Peters, V. A. Kirsh, Nilanjan Chatterjee, M. F. Leitzmann, R. B. Hayes, A. W. Hsing

Research output: Contribution to journalArticle

Abstract

Background: Although most epidemiological studies suggest that non-steroidal anti-inflammatory drug use is inversely associated with prostate cancer risk, the magnitude and specificity of this association remain unclear. Methods: We examined self-reported aspirin and ibuprofen use in relation to prostate cancer risk among 29 450 men ages 55-74 who were initially screened for prostate cancer from 1993 to 2001 in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Men were followed from their first screening exam until 31 December 2009, during which 3575 cases of prostate cancer were identified. Results: After adjusting for potential confounders, the hazard ratios (HRs) of prostate cancer associated with 1 <and 1 ≥ pill of aspirin daily were 0.98 (95% confidence interval (CI), 0.90-1.07) and 0.92 (95% CI: 0.85-0.99), respectively, compared with never use (P for trend 0.04). The effect of taking at least one aspirin daily was more pronounced when restricting the analyses to men older than age 65 or men who had a history of cardiovascular-related diseases or arthritis (HR (95% CI); 0.87 (0.78-0.97), 0.89 (0.80-0.99), and 0.88 (0.78-1.00), respectively). The data did not support an association between ibuprofen use and prostate cancer risk. Conclusion: Daily aspirin use, but not ibuprofen use, was associated with lower risk of prostate cancer risk.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalBritish Journal of Cancer
Volume107
Issue number1
DOIs
StatePublished - Jun 26 2012
Externally publishedYes

Fingerprint

Ibuprofen
Aspirin
Prostatic Neoplasms
Confidence Intervals
Early Detection of Cancer
Ovarian Neoplasms
Arthritis
Epidemiologic Studies
Colorectal Neoplasms
Lung Neoplasms
Anti-Inflammatory Agents
Cardiovascular Diseases
Pharmaceutical Preparations

Keywords

  • cyclooxgenase
  • non-steroidal anti-inflammatory drugs
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Shebl, F. M., Sakoda, L. C., Black, A., Koshiol, J., Andriole, G. L., Grubb, R., ... Hsing, A. W. (2012). Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: A PLCO Study. British Journal of Cancer, 107(1), 207-214. https://doi.org/10.1038/bjc.2012.227

Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer : A PLCO Study. / Shebl, F. M.; Sakoda, L. C.; Black, A.; Koshiol, J.; Andriole, G. L.; Grubb, R.; Church, T. R.; Chia, D.; Zhou, C.; Chu, L. W.; Huang, W. Y.; Peters, U.; Kirsh, V. A.; Chatterjee, Nilanjan; Leitzmann, M. F.; Hayes, R. B.; Hsing, A. W.

In: British Journal of Cancer, Vol. 107, No. 1, 26.06.2012, p. 207-214.

Research output: Contribution to journalArticle

Shebl, FM, Sakoda, LC, Black, A, Koshiol, J, Andriole, GL, Grubb, R, Church, TR, Chia, D, Zhou, C, Chu, LW, Huang, WY, Peters, U, Kirsh, VA, Chatterjee, N, Leitzmann, MF, Hayes, RB & Hsing, AW 2012, 'Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: A PLCO Study', British Journal of Cancer, vol. 107, no. 1, pp. 207-214. https://doi.org/10.1038/bjc.2012.227
Shebl, F. M. ; Sakoda, L. C. ; Black, A. ; Koshiol, J. ; Andriole, G. L. ; Grubb, R. ; Church, T. R. ; Chia, D. ; Zhou, C. ; Chu, L. W. ; Huang, W. Y. ; Peters, U. ; Kirsh, V. A. ; Chatterjee, Nilanjan ; Leitzmann, M. F. ; Hayes, R. B. ; Hsing, A. W. / Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer : A PLCO Study. In: British Journal of Cancer. 2012 ; Vol. 107, No. 1. pp. 207-214.
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