Aspirin antagonism in isoniazid treatment of tuberculosis in mice

Sean T. Byrne, Steven M. Denkin, Ying Zhang

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Salicylate has previously been shown to reduce the susceptibility of Mycobacterium tuberculosis to several drugs in vitro. In this study, aspirin, a salicylate anti-inflammatory, antagonized isoniazid treatment of murine pulmonary tuberculosis, whereas the nonsalicylate ibuprofen did not. These results may have implications on concurrent administration of anti-inflammatory and antituberculosis drugs.

Original languageEnglish (US)
Pages (from-to)794-795
Number of pages2
JournalAntimicrobial agents and chemotherapy
Issue number2
StatePublished - Feb 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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