Changes in the pulmonary arterial tree after experimental aspiration pneumonia have been followed in the dog. Pulmonary arteriography demonstrated marked vasospasm and thrombosis of branches of the pulmonary artery 6 hours after aspiration in untreated animals. In animals treated by immediate positive-pressure ventilation for 6 hours after aspiration, these vascular changes did not occur. It is suggested that these vascular changes may be important events in the pathogenesis of aspiration pneumonia.
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