TY - JOUR
T1 - Aspiration pneumonia
T2 - experimental evaluation of albumin and steroid therapy
AU - Toung, Thomas J
AU - Bordos, D.
AU - Benson, D. W.
AU - Carter, D.
AU - Zuidema, G. D.
AU - Permutt, S.
AU - Cameron, J. L.
PY - 1976
Y1 - 1976
N2 - An experimental model using an ex vivo perfused ventilated canine pulmonary lobe was used to study aspiration pneumonia. After intrabronchial acid instillation, the lobe weight tripled, air way pressure and pulmonary artery pressure doubled, and intrapulmonary shunting increased from 5.5% to 53.4%. If large quantities of albumin were added to the lobe perfusate 5 minutes after intrabronchial acid instillation, weight gain, airway and pulmonary artery pressure, and intrapulmonary shunting were unchanged from control levels. If large quantities of steroid were added to the lobe perfusate 5 minutes after intrabronchial acid instillation, the lobe weight doubled but airway pressure and pulmonary artery pressure, and intra pulmonary shunting were not significantly different from control values. It is surmised that intrapulmonary acid aspiration causes an immediate and marked change in pulmonary capillary permeability. Albumin administration by couteracting this permeability change, and steroid administration by modifying the permeability change, are both beneficial following acid aspiration.
AB - An experimental model using an ex vivo perfused ventilated canine pulmonary lobe was used to study aspiration pneumonia. After intrabronchial acid instillation, the lobe weight tripled, air way pressure and pulmonary artery pressure doubled, and intrapulmonary shunting increased from 5.5% to 53.4%. If large quantities of albumin were added to the lobe perfusate 5 minutes after intrabronchial acid instillation, weight gain, airway and pulmonary artery pressure, and intrapulmonary shunting were unchanged from control levels. If large quantities of steroid were added to the lobe perfusate 5 minutes after intrabronchial acid instillation, the lobe weight doubled but airway pressure and pulmonary artery pressure, and intra pulmonary shunting were not significantly different from control values. It is surmised that intrapulmonary acid aspiration causes an immediate and marked change in pulmonary capillary permeability. Albumin administration by couteracting this permeability change, and steroid administration by modifying the permeability change, are both beneficial following acid aspiration.
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U2 - 10.1097/00000658-197602000-00016
DO - 10.1097/00000658-197602000-00016
M3 - Article
C2 - 1247316
AN - SCOPUS:0017276486
SN - 0309-1708
VL - 183
SP - 179
EP - 184
JO - Unknown Journal
JF - Unknown Journal
IS - 2
ER -