Aspiration pneumonia: experimental evaluation of albumin and steroid therapy

T. J K Toung, D. Bordos, D. W. Benson, D. Carter, G. D. Zuidema, S. Permutt, J. L. Cameron

Research output: Contribution to journalArticle

Abstract

An experimental model using an ex vivo perfused ventilated canine pulmonary lobe was used to study aspiration pneumonia. After intrabronchial acid instillation, the lobe weight tripled, air way pressure and pulmonary artery pressure doubled, and intrapulmonary shunting increased from 5.5% to 53.4%. If large quantities of albumin were added to the lobe perfusate 5 minutes after intrabronchial acid instillation, weight gain, airway and pulmonary artery pressure, and intrapulmonary shunting were unchanged from control levels. If large quantities of steroid were added to the lobe perfusate 5 minutes after intrabronchial acid instillation, the lobe weight doubled but airway pressure and pulmonary artery pressure, and intra pulmonary shunting were not significantly different from control values. It is surmised that intrapulmonary acid aspiration causes an immediate and marked change in pulmonary capillary permeability. Albumin administration by couteracting this permeability change, and steroid administration by modifying the permeability change, are both beneficial following acid aspiration.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalAnnals of Surgery
Volume183
Issue number2
StatePublished - 1976

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Aspiration Pneumonia
Albumins
Steroids
Acids
Pulmonary Artery
Pressure
Lung
Permeability
Air Pressure
Therapeutics
Weights and Measures
Capillary Permeability
Weight Gain
Canidae
Theoretical Models

ASJC Scopus subject areas

  • Surgery

Cite this

Toung, T. J. K., Bordos, D., Benson, D. W., Carter, D., Zuidema, G. D., Permutt, S., & Cameron, J. L. (1976). Aspiration pneumonia: experimental evaluation of albumin and steroid therapy. Annals of Surgery, 183(2), 179-184.

Aspiration pneumonia : experimental evaluation of albumin and steroid therapy. / Toung, T. J K; Bordos, D.; Benson, D. W.; Carter, D.; Zuidema, G. D.; Permutt, S.; Cameron, J. L.

In: Annals of Surgery, Vol. 183, No. 2, 1976, p. 179-184.

Research output: Contribution to journalArticle

Toung, TJK, Bordos, D, Benson, DW, Carter, D, Zuidema, GD, Permutt, S & Cameron, JL 1976, 'Aspiration pneumonia: experimental evaluation of albumin and steroid therapy', Annals of Surgery, vol. 183, no. 2, pp. 179-184.
Toung TJK, Bordos D, Benson DW, Carter D, Zuidema GD, Permutt S et al. Aspiration pneumonia: experimental evaluation of albumin and steroid therapy. Annals of Surgery. 1976;183(2):179-184.
Toung, T. J K ; Bordos, D. ; Benson, D. W. ; Carter, D. ; Zuidema, G. D. ; Permutt, S. ; Cameron, J. L. / Aspiration pneumonia : experimental evaluation of albumin and steroid therapy. In: Annals of Surgery. 1976 ; Vol. 183, No. 2. pp. 179-184.
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