Aspergillus lentulus: An Under-recognized Cause of Antifungal Drug-Resistant Aspergillosis

Saman Nematollahi; Nitipong Permpalung; Sean X. Zhang; Megan Morales; Kieren A. Marr

doi:10.1093/ofid/ofab392

Aspergillus lentulus: An Under-recognized Cause of Antifungal Drug-Resistant Aspergillosis

Saman Nematollahi, Nitipong Permpalung, Sean X. Zhang, Megan Morales, Kieren A. Marr

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Aspergillus lentulus is a drug-resistant species that is phenotypically similar to A. fumigatus. It was discovered as a cause of azole-breakthrough disease, consistent with in vitro resistance. Clinical labs can misidentify the species as fumigatus based on phenotypic typing. We describe 4 recent cases and provide a brief review.

Original language	English (US)
Article number	ofab392
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	8
DOIs	https://doi.org/10.1093/ofid/ofab392
State	Published - Aug 1 2021

Keywords

Aspergillus lentulus
DNA sequencing
MALDI-TOF MS
cryptic species
multidrug resistance
pulmonary aspergillosis

ASJC Scopus subject areas

Infectious Diseases
Oncology

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10.1093/ofid/ofab392

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title = "Aspergillus lentulus: An Under-recognized Cause of Antifungal Drug-Resistant Aspergillosis",

abstract = "Aspergillus lentulus is a drug-resistant species that is phenotypically similar to A. fumigatus. It was discovered as a cause of azole-breakthrough disease, consistent with in vitro resistance. Clinical labs can misidentify the species as fumigatus based on phenotypic typing. We describe 4 recent cases and provide a brief review.",

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AU - Morales, Megan

AU - Marr, Kieren A.

PY - 2021/8/1

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AB - Aspergillus lentulus is a drug-resistant species that is phenotypically similar to A. fumigatus. It was discovered as a cause of azole-breakthrough disease, consistent with in vitro resistance. Clinical labs can misidentify the species as fumigatus based on phenotypic typing. We describe 4 recent cases and provide a brief review.

KW - Aspergillus lentulus

KW - DNA sequencing

KW - MALDI-TOF MS

KW - cryptic species

KW - multidrug resistance

KW - pulmonary aspergillosis

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Aspergillus lentulus: An Under-recognized Cause of Antifungal Drug-Resistant Aspergillosis

Abstract

Keywords

ASJC Scopus subject areas

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