TY - JOUR
T1 - Aspergillosis in lung transplantation
T2 - Incidence, risk factors, and prophylactic strategies
AU - Gordon, S. M.
AU - Avery, R. K.
PY - 2001
Y1 - 2001
N2 - Invasive aspergillosis remains a significant cause of morbidity and mortality in transplantation, especially lung and allogeneic bone marrow transplant recipients. The epidemiology, classic and newly recognized risk factors, and incidence of aspergillosis are reviewed. Risk factors include environmental exposures, airway colonization, profound immunosuppression, neutropenia, prior cytomegalovirus infection, and renal dysfunction. Clinical and radiographic presentations of invasive aspergillosis are discussed, including some unusual manifestations in lung transplant recipients. Early and accurate diagnosis of aspergillosis remains a challenge, and diagnostic strategies are reviewed, with an emphasis on the chest computerized tomography scan and on transbronchial or open lung biopsy. Recent advances include prophylactic and pre-emptive antifungal strategies, newer therapeutic agents, and improved risk stratification.
AB - Invasive aspergillosis remains a significant cause of morbidity and mortality in transplantation, especially lung and allogeneic bone marrow transplant recipients. The epidemiology, classic and newly recognized risk factors, and incidence of aspergillosis are reviewed. Risk factors include environmental exposures, airway colonization, profound immunosuppression, neutropenia, prior cytomegalovirus infection, and renal dysfunction. Clinical and radiographic presentations of invasive aspergillosis are discussed, including some unusual manifestations in lung transplant recipients. Early and accurate diagnosis of aspergillosis remains a challenge, and diagnostic strategies are reviewed, with an emphasis on the chest computerized tomography scan and on transbronchial or open lung biopsy. Recent advances include prophylactic and pre-emptive antifungal strategies, newer therapeutic agents, and improved risk stratification.
KW - Aspergillosis
KW - Lung transplantation
KW - Prophylaxis
UR - http://www.scopus.com/inward/record.url?scp=0034864998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034864998&partnerID=8YFLogxK
U2 - 10.1034/j.1399-3062.2001.003003161.x
DO - 10.1034/j.1399-3062.2001.003003161.x
M3 - Review article
C2 - 11493398
AN - SCOPUS:0034864998
SN - 1398-2273
VL - 3
SP - 161
EP - 167
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
IS - 3
ER -