Aspergillosis in children with cancer

A 34-year experience

Seema Abbasi, Jerry L. Shenep, Walter T. Hughes, Patricia M. Flynn

Research output: Contribution to journalArticle

Abstract

A retrospective review of medical records, microbiology and pathology laboratory records, and nosocomial infection surveillance data was undertaken to describe the experience with culture-documented aspergillus infection in pediatric cancer patients at our facility. Sixty-six patients were identified from a 34-year period. The most common underlying diagnosis was leukemia. Risk factors included neutropenia, immunosuppression, and prior antibiotic therapy. On the basis of clinical presentation, 23 patients were believed to have disseminated disease and 43 to have localized disease. The lung was the most frequently affected organ. Despite aggressive medical and surgical management, overall mortality was 85% within the first year after diagnosis. Patients who presented with disease in sites other than the lungs fared better than patients with initial pulmonary involvement (P = .0014). Aspergillosis continues to be associated with poor outcome. Development of improved medical and adjuvant therapies, including surgery, is warranted.

Original languageEnglish (US)
Pages (from-to)1210-1219
Number of pages10
JournalClinical Infectious Diseases
Volume29
Issue number5
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Aspergillosis
Neoplasms
Lung
Laboratory Infection
Aspergillus
Cross Infection
Microbiology
Neutropenia
Immunosuppression
Medical Records
Leukemia
Pediatrics
Pathology
Anti-Bacterial Agents
Mortality
Therapeutics
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Abbasi, S., Shenep, J. L., Hughes, W. T., & Flynn, P. M. (1999). Aspergillosis in children with cancer: A 34-year experience. Clinical Infectious Diseases, 29(5), 1210-1219. https://doi.org/10.1086/313445

Aspergillosis in children with cancer : A 34-year experience. / Abbasi, Seema; Shenep, Jerry L.; Hughes, Walter T.; Flynn, Patricia M.

In: Clinical Infectious Diseases, Vol. 29, No. 5, 1999, p. 1210-1219.

Research output: Contribution to journalArticle

Abbasi, S, Shenep, JL, Hughes, WT & Flynn, PM 1999, 'Aspergillosis in children with cancer: A 34-year experience', Clinical Infectious Diseases, vol. 29, no. 5, pp. 1210-1219. https://doi.org/10.1086/313445
Abbasi, Seema ; Shenep, Jerry L. ; Hughes, Walter T. ; Flynn, Patricia M. / Aspergillosis in children with cancer : A 34-year experience. In: Clinical Infectious Diseases. 1999 ; Vol. 29, No. 5. pp. 1210-1219.
@article{3dc7544dacae4b65bb0b9d1e68484d32,
title = "Aspergillosis in children with cancer: A 34-year experience",
abstract = "A retrospective review of medical records, microbiology and pathology laboratory records, and nosocomial infection surveillance data was undertaken to describe the experience with culture-documented aspergillus infection in pediatric cancer patients at our facility. Sixty-six patients were identified from a 34-year period. The most common underlying diagnosis was leukemia. Risk factors included neutropenia, immunosuppression, and prior antibiotic therapy. On the basis of clinical presentation, 23 patients were believed to have disseminated disease and 43 to have localized disease. The lung was the most frequently affected organ. Despite aggressive medical and surgical management, overall mortality was 85{\%} within the first year after diagnosis. Patients who presented with disease in sites other than the lungs fared better than patients with initial pulmonary involvement (P = .0014). Aspergillosis continues to be associated with poor outcome. Development of improved medical and adjuvant therapies, including surgery, is warranted.",
author = "Seema Abbasi and Shenep, {Jerry L.} and Hughes, {Walter T.} and Flynn, {Patricia M.}",
year = "1999",
doi = "10.1086/313445",
language = "English (US)",
volume = "29",
pages = "1210--1219",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Aspergillosis in children with cancer

T2 - A 34-year experience

AU - Abbasi, Seema

AU - Shenep, Jerry L.

AU - Hughes, Walter T.

AU - Flynn, Patricia M.

PY - 1999

Y1 - 1999

N2 - A retrospective review of medical records, microbiology and pathology laboratory records, and nosocomial infection surveillance data was undertaken to describe the experience with culture-documented aspergillus infection in pediatric cancer patients at our facility. Sixty-six patients were identified from a 34-year period. The most common underlying diagnosis was leukemia. Risk factors included neutropenia, immunosuppression, and prior antibiotic therapy. On the basis of clinical presentation, 23 patients were believed to have disseminated disease and 43 to have localized disease. The lung was the most frequently affected organ. Despite aggressive medical and surgical management, overall mortality was 85% within the first year after diagnosis. Patients who presented with disease in sites other than the lungs fared better than patients with initial pulmonary involvement (P = .0014). Aspergillosis continues to be associated with poor outcome. Development of improved medical and adjuvant therapies, including surgery, is warranted.

AB - A retrospective review of medical records, microbiology and pathology laboratory records, and nosocomial infection surveillance data was undertaken to describe the experience with culture-documented aspergillus infection in pediatric cancer patients at our facility. Sixty-six patients were identified from a 34-year period. The most common underlying diagnosis was leukemia. Risk factors included neutropenia, immunosuppression, and prior antibiotic therapy. On the basis of clinical presentation, 23 patients were believed to have disseminated disease and 43 to have localized disease. The lung was the most frequently affected organ. Despite aggressive medical and surgical management, overall mortality was 85% within the first year after diagnosis. Patients who presented with disease in sites other than the lungs fared better than patients with initial pulmonary involvement (P = .0014). Aspergillosis continues to be associated with poor outcome. Development of improved medical and adjuvant therapies, including surgery, is warranted.

UR - http://www.scopus.com/inward/record.url?scp=0033512462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033512462&partnerID=8YFLogxK

U2 - 10.1086/313445

DO - 10.1086/313445

M3 - Article

VL - 29

SP - 1210

EP - 1219

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 5

ER -