Aspartate aminotransferase-To-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis-coinfected men

Jennifer C. Price; Eric C. Seaberg; Valentina Stosor; Mallory D. Witt; Carling D. Lellock; Chloe L. Thio

doi:10.1097/QAD.0000000000001977

Aspartate aminotransferase-To-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis-coinfected men

Jennifer C. Price, Eric C. Seaberg, Valentina Stosor, Mallory D. Witt, Carling D. Lellock, Chloe L. Thio

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The utility of longitudinal AST-To-platelet ratio index (APRI), a surrogate for hepatic fibrosis, is unknown.We compared APRI up to 9 years before liver-related death among 57 cases of viral hepatitis-infected men (91% HIVR) to matched controls. APRI was stable among controls but, among cases, increased 4.6%/year from 9 to 3 years predeath (PU0.10) and 30%/year during the 3 years predeath (P0.001). Thus, rapid APRI increase may predict impending liver-related death in HIV-viral hepatitis coinfection.

Original language	English (US)
Pages (from-to)	2636-2638
Number of pages	3
Journal	AIDS
Volume	32
Issue number	17
DOIs	https://doi.org/10.1097/QAD.0000000000001977
State	Published - 2018

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

Access to Document

10.1097/QAD.0000000000001977

Cite this

@article{c4aab3b7b3484c778795f0e006bbaa21,

title = "Aspartate aminotransferase-To-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis-coinfected men",

abstract = "The utility of longitudinal AST-To-platelet ratio index (APRI), a surrogate for hepatic fibrosis, is unknown.We compared APRI up to 9 years before liver-related death among 57 cases of viral hepatitis-infected men (91% HIVR) to matched controls. APRI was stable among controls but, among cases, increased 4.6%/year from 9 to 3 years predeath (PU0.10) and 30%/year during the 3 years predeath (P0.001). Thus, rapid APRI increase may predict impending liver-related death in HIV-viral hepatitis coinfection.",

author = "Price, {Jennifer C.} and Seaberg, {Eric C.} and Valentina Stosor and Witt, {Mallory D.} and Lellock, {Carling D.} and Thio, {Chloe L.}",

year = "2018",

doi = "10.1097/QAD.0000000000001977",

language = "English (US)",

volume = "32",

pages = "2636--2638",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "17",

}

TY - JOUR

T1 - Aspartate aminotransferase-To-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis-coinfected men

AU - Price, Jennifer C.

AU - Seaberg, Eric C.

AU - Stosor, Valentina

AU - Witt, Mallory D.

AU - Lellock, Carling D.

AU - Thio, Chloe L.

PY - 2018

Y1 - 2018

N2 - The utility of longitudinal AST-To-platelet ratio index (APRI), a surrogate for hepatic fibrosis, is unknown.We compared APRI up to 9 years before liver-related death among 57 cases of viral hepatitis-infected men (91% HIVR) to matched controls. APRI was stable among controls but, among cases, increased 4.6%/year from 9 to 3 years predeath (PU0.10) and 30%/year during the 3 years predeath (P0.001). Thus, rapid APRI increase may predict impending liver-related death in HIV-viral hepatitis coinfection.

AB - The utility of longitudinal AST-To-platelet ratio index (APRI), a surrogate for hepatic fibrosis, is unknown.We compared APRI up to 9 years before liver-related death among 57 cases of viral hepatitis-infected men (91% HIVR) to matched controls. APRI was stable among controls but, among cases, increased 4.6%/year from 9 to 3 years predeath (PU0.10) and 30%/year during the 3 years predeath (P0.001). Thus, rapid APRI increase may predict impending liver-related death in HIV-viral hepatitis coinfection.

UR - http://www.scopus.com/inward/record.url?scp=85055836251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055836251&partnerID=8YFLogxK

U2 - 10.1097/QAD.0000000000001977

DO - 10.1097/QAD.0000000000001977

M3 - Article

C2 - 30096072

AN - SCOPUS:85055836251

SN - 0269-9370

VL - 32

SP - 2636

EP - 2638

JO - AIDS

JF - AIDS

IS - 17

ER -

Aspartate aminotransferase-To-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis-coinfected men

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this