Ascites volumes and the ovarian cancer microenvironment

Research output: Contribution to journalArticlepeer-review

Abstract

Epithelial ovarian cancer is the leading cause of death from gynecologic malignancy among women in developed countries. Epithelial ovarian cancer has a poor prognosis, due to the aggressive characteristics of the disease combined with the lack of effective therapies. Options for late-stage ovarian cancer are limited and invasive, especially once malignant ascites develops. Malignant ascites, a complication observed in terminal ovarian cancer, significantly contributes to poor quality of life and to mortality. Excess accumulation of fluid in the peritoneal cavity occurs due to a combination of impaired fluid drainage and increased net filtration, mostly due to increasing intraperitoneal vascular permeability. Here we applied non-invasive magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) of syngeneic mouse tumors in vivo, and high-resolution 1H MRS of mouse tumor extracts, to characterize the relationship between ascites volumes and the vasculature and metabolism of an experimental model of ovarian cancer. Differences were observed in the tumor vasculature and metabolism in tumors based on ascites volumes that provide new insights into the development of this condition.

Original languageEnglish (US)
Article number595
JournalFrontiers in Oncology
Volume8
Issue numberDEC
DOIs
StatePublished - 2018

Keywords

  • Ascites
  • MRI
  • Ovarian cancer
  • Total choline
  • Vascular volume and permeability

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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