TY - GEN
T1 - AS3MT, locus 10q24 and arsenic metabolism biomarkers in American Indians
T2 - 6th International Congress on Arsenic in the Environment, AS 2016
AU - Balakrishnan, P.
AU - Vaidya, D.
AU - Franceschini, N.
AU - Voruganti, V. S.
AU - Gribble, M.
AU - Haack, K.
AU - Laston, S.
AU - Umans, J.
AU - Francesconi, K.
AU - Goessler, W.
AU - North, K.
AU - Lee, E.
AU - Yracheta, J.
AU - Best, L.
AU - Maccluer, J.
AU - Kent, J.
AU - Cole, S.
AU - Navas-Acien, A.
N1 - Funding Information:
Work funded by National Institute of Environmental Health Sciences (R01ES021367, T32 ES007141-32).
Publisher Copyright:
© 2016 Taylor & Francis Group, London.
PY - 2016
Y1 - 2016
N2 - Genetic determinants may partly explain metabolic differences of inorganic arsenic(iAs) between individuals. We investigated association of arsenic metabolism biomarkers with variants previously associated with cardiometabolic traits (∼200,000, Illumina Cardio MetaboChip) or arsenic metabolism (670) among 2,428 American Indian participants in the Strong Heart Family Study. Arsenic traits included percent urine arsenic species, measured by HPLC-ICPMS, (iAs, monomethylarsonate [MMA], dimethylarsinate [DMA], divided by their sum and principal components of the arsenic species. Each phenotype was regressed on allele dosage, accounting for familial relatedness, age, sex, total arsenic levels, and population stratification. SNP associations were stratified by center and meta-analyzed. Multiple testing was accounted using Bonferroni. 10q24 variants were statistically significant for all arsenic phenotypes. Index SNP for percent arsenic species (rs12768205) and principal components (rs3740394, rs3740393) were located near AS3MT, whose gene product catalyzes methylation of iAs to MMA and DMA. Among the candidate arsenic variant associations, functional 10q24 SNPs were most significant (P<9.33e−5).
AB - Genetic determinants may partly explain metabolic differences of inorganic arsenic(iAs) between individuals. We investigated association of arsenic metabolism biomarkers with variants previously associated with cardiometabolic traits (∼200,000, Illumina Cardio MetaboChip) or arsenic metabolism (670) among 2,428 American Indian participants in the Strong Heart Family Study. Arsenic traits included percent urine arsenic species, measured by HPLC-ICPMS, (iAs, monomethylarsonate [MMA], dimethylarsinate [DMA], divided by their sum and principal components of the arsenic species. Each phenotype was regressed on allele dosage, accounting for familial relatedness, age, sex, total arsenic levels, and population stratification. SNP associations were stratified by center and meta-analyzed. Multiple testing was accounted using Bonferroni. 10q24 variants were statistically significant for all arsenic phenotypes. Index SNP for percent arsenic species (rs12768205) and principal components (rs3740394, rs3740393) were located near AS3MT, whose gene product catalyzes methylation of iAs to MMA and DMA. Among the candidate arsenic variant associations, functional 10q24 SNPs were most significant (P<9.33e−5).
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U2 - 10.1201/b20466-206
DO - 10.1201/b20466-206
M3 - Conference contribution
AN - SCOPUS:85016926636
SN - 9781138029415
T3 - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
SP - 443
EP - 445
BT - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
A2 - Bhattacharya, Prosun
A2 - Jacks, Gunnar
A2 - Bundschuh, Jochen
A2 - Bhattacharya, Prosun
A2 - Vahter, Marie
A2 - Jarsjo, Jerker
A2 - Jarsjo, Jerker
A2 - Kumpiene, Jurate
A2 - Ahmad, Arslan
A2 - Sparrenbom, Charlotte
A2 - Donselaar, Marinus Eric
A2 - Bundschuh, Jochen
A2 - Naidu, Ravi
A2 - Naidu, Ravi
PB - CRC Press/Balkema
Y2 - 19 June 2016 through 23 June 2016
ER -