As time flies by: Investigating cardiac aging in the short-lived Drosophila model

Anna C. Blice-Baum, Maria Clara Guida, Paul S. Hartley, Peter D. Adams, Rolf Bodmer, Anthony Cammarato

Research output: Contribution to journalReview article

Abstract

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.

Original languageEnglish (US)
Pages (from-to)1831-1844
Number of pages14
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1865
Issue number7
DOIs
StatePublished - Jul 1 2019

Keywords

  • Cardiac aging
  • Epigenetics
  • Fruit fly
  • Obesity
  • Proteostasis

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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