As time flies by: Investigating cardiac aging in the short-lived Drosophila model

Anna C. Blice-Baum, Maria Clara Guida, Paul S. Hartley, Peter D. Adams, Rolf Bodmer, Anthony Ross Cammarato

Research output: Contribution to journalArticle

Abstract

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
DOIs
StateAccepted/In press - Jan 1 2018

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Drosophila melanogaster
Developed Countries
Diptera
Health Care Costs
Drosophila
Molecular Biology
Fruit
Cardiovascular Diseases

Keywords

  • Cardiac aging
  • Epigenetics
  • Fruit fly
  • Obesity
  • Proteostasis

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

As time flies by : Investigating cardiac aging in the short-lived Drosophila model. / Blice-Baum, Anna C.; Guida, Maria Clara; Hartley, Paul S.; Adams, Peter D.; Bodmer, Rolf; Cammarato, Anthony Ross.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, 01.01.2018.

Research output: Contribution to journalArticle

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