Arylesterase phenotype-specific positive association between arylesterase activity and cholinesterase specific activity in human serum

Yutaka Aoki, Kathy J. Helzlsouer, Paul T. Strickland

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Cholinesterase (ChE) specific activity is the ratio of ChE activity to ChE mass and, as a biomarker of exposure to cholinesterase inhibitors, has a potential advantage over simple ChE activity. Objective: To examine the association of several potential correlates (serum arylesterase/paraoxonase activity, serum albumin, sex, age, month of blood collection, and smoking) with plasma ChE specific activity. Methods: We analyzed data from 195 cancer-free controls from a nested case-control study, accounting for potential confounding. Results: Arylesterase activity had an independent, statistically significant positive association with ChE specific activity, and its magnitude was the greatest for the arylesterase phenotype corresponding to the QQ PON1192 genotype followed by phenotypes corresponding to QR and RR genotypes. Serum albumin was positively associated with ChE specific activity. Conclusions: Plasma arylesterase activity was positively associated with plasma ChE specific activity. This observation is consistent with protection conferred by a metabolic phenotype resulting in reduced internal dose.

Original languageEnglish (US)
Pages (from-to)1422-1443
Number of pages22
JournalInternational journal of environmental research and public health
Volume11
Issue number2
DOIs
StatePublished - Jan 27 2014

Keywords

  • Albumin
  • Arylesterase
  • Biomarkers
  • Genetic polymorphism
  • Internal dose
  • Paraoxonase
  • Pseudocholinesterase

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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