ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

Laura Cato, Jonas de Tribolet-Hardy, Irene Lee, Jaice T. Rottenberg, Ilsa Coleman, Diana Melchers, René Houtman, Tengfei Xiao, Wei Li, Takuma Uo, Shihua Sun, Nane C. Kuznik, Bettina Göppert, Fatma Ozgun, Martin E. van Royen, Adriaan B. Houtsmuller, Raga Vadhi, Prakash K. Rao, Lewyn Li, Steven P. BalkRobert B. Den, Bruce J. Trock, R. Jeffrey Karnes, Robert B. Jenkins, Eric A. Klein, Elai Davicioni, Friederike J. Gruhl, Henry W. Long, X. Shirley Liu, Andrew C.B. Cato, Nathan A. Lack, Peter S. Nelson, Stephen R. Plymate, Anna C. Groner, Myles Brown

Research output: Contribution to journalArticle

Abstract

Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.

Original languageEnglish (US)
Pages (from-to)401-413.e6
JournalCancer cell
Volume35
Issue number3
DOIs
StatePublished - Mar 18 2019
Externally publishedYes

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Keywords

  • androgen receptor (AR)
  • AR variant v7 (ARv7)
  • castration-resistant prostate cancer (CRPC)
  • transcription

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Cato, L., de Tribolet-Hardy, J., Lee, I., Rottenberg, J. T., Coleman, I., Melchers, D., Houtman, R., Xiao, T., Li, W., Uo, T., Sun, S., Kuznik, N. C., Göppert, B., Ozgun, F., van Royen, M. E., Houtsmuller, A. B., Vadhi, R., Rao, P. K., Li, L., ... Brown, M. (2019). ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. Cancer cell, 35(3), 401-413.e6. https://doi.org/10.1016/j.ccell.2019.01.008