Artificial reporter gene providing MRI contrast based on proton exchange

Assaf A. Gilad, Michael T. McMahon, Piotr Walczak, Paul T. Winnard, Venu Raman, Hanneke W.M. Van Laarhoven, Cynthia M. Skoglund, Jeff W.M. Bulte, Peter C.M. Van Zijl

Research output: Contribution to journalArticlepeer-review

Abstract

Existing magnetic resonance reporter genes all rely on the presence of (super)paramagnetic substances and employ water relaxation to gain contrast. We designed a nonmetallic, biodegradable, lysine rich-protein (LRP) reporter, the prototype of a potential family of genetically engineered reporters expressing artificial proteins with frequency-selective contrast. This endogenous contrast, based on transfer of radiofrequency labeling from the reporter's amide protons to water protons, can be switched on and off.

Original languageEnglish (US)
Pages (from-to)217-219
Number of pages3
JournalNature biotechnology
Volume25
Issue number2
DOIs
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

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