Artificial antigen-presenting cells: Artificial solutions for real diseases

Mathias Oelke, Christine Krueger, Robert L. Giuntoli, Jonathan P. Schneck

Research output: Contribution to journalReview article

Abstract

Adoptive immunotherapy, which involves the transfer of autologous antigen-specific T cells generated ex vivo, is a promising strategy to treat a variety of life-threatening diseases. Unfortunately, current approaches for generating sufficient numbers of antigen-specific T cells lack the ability to serve as reproducible and economically viable methods. This has spurred the development of both cell- and non-cell-based artificial antigen-presenting cells to alleviate problems associated with peptide-loaded dendritic cells in current approaches to adoptive immunotherapy. Here, we review new strategies for the ex vivo generation of antigen-specific T cells and their clinical application. These new approaches have the potential to spearhead a new era of successful adoptive immunotherapy for cancer and infectious diseases.

Original languageEnglish (US)
Pages (from-to)412-420
Number of pages9
JournalTrends in Molecular Medicine
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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