Arterial thromboembolism in cancer patients treated with cisplatin: A systematic review and meta-analysis

Tracy Proverbs-Singh, Sophia K. Chiu, Ziyue Liu, Sonia Seng, Guru Sonpavde, Toni K. Choueiri, Che Kai Tsao, Menggang Yu, Noah M. Hahn, William K. Oh, Matthew D. Galsky

Research output: Contribution to journalReview articlepeer-review


Cisplatin has been associated with an increased risk of arterial thromboembolic events (ATEs). However, because this association is mostly based on case reports and retrospective studies, we conducted a systemic review and meta-analysis of randomized controlled trials evaluating the incidence and risk of ATEs associated with cisplatin. Eligible studies included prospective randomized phase II and III trials evaluating cisplatin-based vs non-cisplatin-based chemotherapy in patients with solid tumors, which were identified from PubMed articles published between 1990 and 2010. Incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated using a random effects model. A total of 8216 patients from 38 trials were included. Among patients treated with cisplatin-based chemotherapy, the summary incidence of ATEs was 0.67% (95% CI 0.40% to 0.95%), and the RR of ATEs was 1.36 (95% CI 0.86 to 2.17; P .19). No increase in ATEs was detected in any prespecified subgroup.

Original languageEnglish (US)
Pages (from-to)1837-1840
Number of pages4
JournalJournal of the National Cancer Institute
Issue number23
StatePublished - Dec 2012
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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