Arterial spin-labeling parameters influence signal variability and estimated regional relative cerebral blood flow in normal aging and mild cognitive impairment: FAIR versus PICORE techniques

K. O. Lövblad, M. L. Montandon, M. Viallon, C. Rodriguez, S. Toma, X. Golay, P. Giannakopoulos, S. Haller

Research output: Contribution to journalArticle


BACKGROUNDANDPURPOSE: Arterial spin-labeling is a noninvasive method to map cerebral blood flow, which might be useful for early diagnosis of neurodegenerative diseases. We directly compared 2 arterial spin-labeling techniques in healthy elderly controls and individuals with mild cognitive impairment. MATERIALS AND METHODS: This prospective study was approved by the local ethics committee and included 198 consecutive healthy controls (mean age, 73.65±4.02 years) and 43 subjects with mild cognitive impairment (mean age, 73.38±5.85 years). Two pulsed arterial spin-labeling sequences were performed at 3T: proximal inversion with a control for off-resonance effects (PICORE) and flow-sensitive alternating inversion recovery technique (FAIR). Relative cerebral blood flow maps were calculated by using commercial software and standard parameters. Data analysis included spatial normalization of gray matter- corrected relative CBF maps, whole-brain average, and voxelwise comparison of both arterial spin-labeling sequences. RESULTS: Overall, FAIR yielded higher relative CBF values compared with PICORE (controls, 32.7±7.1 versus 30.0±13.1 mL/min/100 g, P= .05; mild cognitive impairment, 29.8±5.4 versus 26.2±8.6 mL/min/100 g, P

Original languageEnglish (US)
Pages (from-to)1231-1236
Number of pages6
JournalAmerican Journal of Neuroradiology
Issue number7
StatePublished - Jul 1 2015
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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