TY - JOUR
T1 - Arterial Spin Labeling
T2 - Benefits and Pitfalls of High Magnetic Field
AU - Golay, Xavier
AU - Petersen, Esben T.
N1 - Funding Information:
This work was supported in parts by Grant Number NHGA-RPR/04012 from the National Healthcare Group/ Singhealth Foundation of Singapore, and Grant Numbers NMRC/0855/2004 and NMRC/0919/2004 from the National Medical Research Council of Singapore.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2006/5
Y1 - 2006/5
N2 - Arterial spin labeling (ASL) techniques are MR imaging methods designed to measure the endogenous perfusion signal coming from arterial blood by manipulation of its magnetization. These methods are based on the subtraction of two consecutively acquired images: one acquired after preparation of the arterial blood magnetization upstream to the area of interest, and the second without any manipulation of its arterial magnetization. The subtraction of both images provides information on the perfusion of the tissue present in the slice of interest. Because ASL is a very low SNR technique, the shift from 1.5 T to 3.0 T should be regarded as a great way to increase signal-to-noise ratio (SNR). Furthermore, the concomitant increase in blood T1 should improve the SNR of ASL further. Other effects related to poorer magnetic filed homogeneities and reduced T2 relaxation times, however, will counterbalance both effects partially. In this article, the pros and cons of the use of ASL at high field are summarized, after a brief description of the major techniques used and their theoretical limitations. Finally, a summary of the few existing dedicated ASL perfusion techniques available are presented.
AB - Arterial spin labeling (ASL) techniques are MR imaging methods designed to measure the endogenous perfusion signal coming from arterial blood by manipulation of its magnetization. These methods are based on the subtraction of two consecutively acquired images: one acquired after preparation of the arterial blood magnetization upstream to the area of interest, and the second without any manipulation of its arterial magnetization. The subtraction of both images provides information on the perfusion of the tissue present in the slice of interest. Because ASL is a very low SNR technique, the shift from 1.5 T to 3.0 T should be regarded as a great way to increase signal-to-noise ratio (SNR). Furthermore, the concomitant increase in blood T1 should improve the SNR of ASL further. Other effects related to poorer magnetic filed homogeneities and reduced T2 relaxation times, however, will counterbalance both effects partially. In this article, the pros and cons of the use of ASL at high field are summarized, after a brief description of the major techniques used and their theoretical limitations. Finally, a summary of the few existing dedicated ASL perfusion techniques available are presented.
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U2 - 10.1016/j.nic.2006.02.003
DO - 10.1016/j.nic.2006.02.003
M3 - Review article
C2 - 16731365
AN - SCOPUS:33646844606
SN - 1052-5149
VL - 16
SP - 259
EP - 268
JO - Neuroimaging Clinics of North America
JF - Neuroimaging Clinics of North America
IS - 2
ER -