Arterial Spin Labeling: Benefits and Pitfalls of High Magnetic Field

Xavier Golay, Esben T. Petersen

Research output: Contribution to journalArticle

Abstract

Arterial spin labeling (ASL) techniques are MR imaging methods designed to measure the endogenous perfusion signal coming from arterial blood by manipulation of its magnetization. These methods are based on the subtraction of two consecutively acquired images: one acquired after preparation of the arterial blood magnetization upstream to the area of interest, and the second without any manipulation of its arterial magnetization. The subtraction of both images provides information on the perfusion of the tissue present in the slice of interest. Because ASL is a very low SNR technique, the shift from 1.5 T to 3.0 T should be regarded as a great way to increase signal-to-noise ratio (SNR). Furthermore, the concomitant increase in blood T1 should improve the SNR of ASL further. Other effects related to poorer magnetic filed homogeneities and reduced T2 relaxation times, however, will counterbalance both effects partially. In this article, the pros and cons of the use of ASL at high field are summarized, after a brief description of the major techniques used and their theoretical limitations. Finally, a summary of the few existing dedicated ASL perfusion techniques available are presented.

Original languageEnglish (US)
Pages (from-to)259-268
Number of pages10
JournalNeuroimaging Clinics of North America
Volume16
Issue number2
DOIs
StatePublished - May 2006
Externally publishedYes

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Signal-To-Noise Ratio
Magnetic Fields
Perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

Cite this

Arterial Spin Labeling : Benefits and Pitfalls of High Magnetic Field. / Golay, Xavier; Petersen, Esben T.

In: Neuroimaging Clinics of North America, Vol. 16, No. 2, 05.2006, p. 259-268.

Research output: Contribution to journalArticle

Golay, Xavier ; Petersen, Esben T. / Arterial Spin Labeling : Benefits and Pitfalls of High Magnetic Field. In: Neuroimaging Clinics of North America. 2006 ; Vol. 16, No. 2. pp. 259-268.
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