Arterial spin labeling and blood oxygen level-dependent MRI cerebrovascular reactivity in cerebrovascular disease: A systematic review and meta-analysis

Diederik P.J. Smeeing, Jeroen Hendrikse, Esben T. Petersen, Manus J. Donahue, Jill B. De Vis

Research output: Contribution to journalReview article

Abstract

Background: The cerebrovascular reactivity (CVR) results of blood oxygen level-dependent (BOLD) and arterial spin labeling (ASL) MRI studies performed in patients with cerebrovascular disease (steno-occlusive vascular disease or stroke) were systematically reviewed. Summary: Thirty-one articles were included. Twenty-three (74.2%) studies used BOLD MRI to evaluate the CVR, 4 (12.9%) studies used ASL MRI and 4 (12.9%) studies used both BOLD and ASL MRI. Thirteen studies (3 significant) found a lower BOLD CVR, 2 studies found a similar CVR and 3 studies found a higher CVR in the ipsilateral compared to the contralateral hemisphere. Nine (5 significant) out of 10 studies found a lower BOLD CVR in the ipsilateral hemispheres of patients compared to controls. Six studies (2 significant) found a lower ASL CVR in the ipsilateral compared to the contralateral hemispheres. Three out of 5 studies found a significant lower ASL CVR in the ipsilateral hemispheres of patients compared to controls. Key Messages: This review brings support for a reduced BOLD and ASL CVR in the ipsilateral hemisphere of patients with cerebrovascular disease. We suggest that future studies will be performed in a uniform way so reference values can be established and could be used to guide treatment decisions in patients with cerebrovascular disease.

Original languageEnglish (US)
Pages (from-to)288-307
Number of pages20
JournalCerebrovascular Diseases
Volume42
Issue number3-4
DOIs
StatePublished - Jul 1 2016

Keywords

  • Arterial spin labeling
  • Blood oxygen level-dependent
  • Cerebral hemodynamics
  • Cerebrovascular reserve capacity
  • MRI
  • Reactivity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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