Arterial pressure and aging

Research output: Contribution to journalArticle

Abstract

Systolic arterial pressure increases with aging. This increase encompasses both the clinically normal and hypertensive ranges of pressure and is due in part to arterial stiffening. To what extent it may be modulated by life style changes that accompany aging is unknown. The stiffer arterial tree transmits the pulse wave with a higher velocity such that reflected waves return to the aortic root during the ejection period. This causes the aortic impedance to increase at this time, leading to a late peak in systolic pressure. Cardiac adaptation to these vascular changes include left ventricular hypertrophy and prolonged Ca2+ activation of contractile proteins leading to prolonged contraction. The resultant delayed contractile relaxation, in part, leads to a slower velocity of early left ventricular filling; however, this is offset by an enhanced atrial contribution to filling. These myocardial adaptations with aging, which in animal models appear, in part at least, to be controlled from within the genome permit a relatively normal heart volume and ejection fraction in the presence of chronically elevated afterload. These changes that occur with aging in otherwise healthy individuals can occur at a younger age in clinical hypertensives and can be produced in young experimental animals by hypertension. Thus, aging has sometimes been referred to as blunted hypertension, or hypertension as accelerated aging.

Original languageEnglish (US)
JournalInternational Journal of Cardiology
Volume25
Issue numberSUPPL. 1
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Arterial Pressure
Hypertension
Blood Pressure
Contractile Proteins
Cardiac Volume
Left Ventricular Hypertrophy
Electric Impedance
Blood Vessels
Life Style
Reference Values
Animal Models
Genome
Pressure

Keywords

  • Aging
  • Arterial pressure
  • Calcium
  • Cardiac hypertrophy
  • Hypertension

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Arterial pressure and aging. / Lakatta, Edward.

In: International Journal of Cardiology, Vol. 25, No. SUPPL. 1, 1989.

Research output: Contribution to journalArticle

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