Arterial oxygen thresholds for cardiac adjustments to hypoxia in conscious dogs

Raymond C Koehler, J. A. Krasney

Research output: Contribution to journalArticle

Abstract

Cardiac responses to hypoxia were analyzed as a continuous function of Pa02 in 5 conscious, tracheostomized dogs chronically instrumented with aortic blood flow transducers, left atrial and arterial catheters, and solid state left ventricular (LV) pressure transducers. The dogs rebreathed air from a 40 L Douglas bag with a CO2 absorber. This resulted in a gradual decline in Pa02 from 72 mm Hg (±1.5SE) to 28 mm Hg (±1.0) over a period of 31 min (±2.5). Heart rate and LV dP/dt max were elevated significantly above control values at a Pa02 of 55 mm Hg (p2 level of 40 mm Hg (p2 level of 35 mm Hg (p2 level of 32.5 mm Hg (p2 (28 mm Hg) were similar to those the authors have previously described in dogs breathing 7% FIO2 (Fed. Proc. 35(3), 1976). These results indicate that although improved ventricular contractile performance is detected at a Pa02 of 55 mm Hg, lower Pa02 levels (40 mm Hg) are required to elicit well-defined increases in cardiac output.

Original languageEnglish (US)
JournalFederation proceedings
Volume36
Issue number3
StatePublished - 1977
Externally publishedYes

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Dogs
Oxygen
Pressure Transducers
Ventricular Pressure
Transducers
Cardiac Output
Respiration
Catheters
Heart Rate
Air
Hypoxia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Arterial oxygen thresholds for cardiac adjustments to hypoxia in conscious dogs. / Koehler, Raymond C; Krasney, J. A.

In: Federation proceedings, Vol. 36, No. 3, 1977.

Research output: Contribution to journalArticle

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abstract = "Cardiac responses to hypoxia were analyzed as a continuous function of Pa02 in 5 conscious, tracheostomized dogs chronically instrumented with aortic blood flow transducers, left atrial and arterial catheters, and solid state left ventricular (LV) pressure transducers. The dogs rebreathed air from a 40 L Douglas bag with a CO2 absorber. This resulted in a gradual decline in Pa02 from 72 mm Hg (±1.5SE) to 28 mm Hg (±1.0) over a period of 31 min (±2.5). Heart rate and LV dP/dt max were elevated significantly above control values at a Pa02 of 55 mm Hg (p2 level of 40 mm Hg (p2 level of 35 mm Hg (p2 level of 32.5 mm Hg (p2 (28 mm Hg) were similar to those the authors have previously described in dogs breathing 7{\%} FIO2 (Fed. Proc. 35(3), 1976). These results indicate that although improved ventricular contractile performance is detected at a Pa02 of 55 mm Hg, lower Pa02 levels (40 mm Hg) are required to elicit well-defined increases in cardiac output.",
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