Arterial line filtration protects brain microcirculation during cardiopulmonary bypass in the pig

Jens Waaben, Hans Rahbek Sørensen, Ulrich L.S. Andersen, Kaj Gefke, Jens Lund, Søren Aggestrup, Bent Husum, Henning Laursen, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

Microemboli in the brain may inhibit brain function during cardiopulmonary bypass, and in a previous study in pigs of normothermic nonpulsatile bypass we reported a significant decrease in cerebral glucose consumption secondary to interruption of the capillary flow, possibly caused by microemboli. In the present study we measured the regional cerebral glucose consumption and the regional capillary diffusion capacity (that is, the number of perfused capillaries) in 10 different brain regions in two separate groups of animals with and without an arterial filter during normothermic cardiopulmonary bypass. Inclusion of a 40 jum arterial filter in the bypass circuit increased the regional brain glucose consumption 27 % (median; range −12 % to 145 %) and regional capillary diffusion capacity increased 123% (median; range 36% to 829%). No change in brain histologic features, the cerebrovascular permeability to serum proteins, or cerebral water content was observed. The arterial filter probably protects the cerebral microcirculation and prevents the decrease in cerebral glucose consumption otherwise seen during bypass.

Original languageEnglish (US)
Pages (from-to)1030-1035
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume107
Issue number4
DOIs
StatePublished - Jan 1 1994

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ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Waaben, J., Sørensen, H. R., Andersen, U. L. S., Gefke, K., Lund, J., Aggestrup, S., Husum, B., Laursen, H., & Gjedde, A. (1994). Arterial line filtration protects brain microcirculation during cardiopulmonary bypass in the pig. Journal of Thoracic and Cardiovascular Surgery, 107(4), 1030-1035. https://doi.org/10.1016/S0022-5223(94)70377-9