Abstract
We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells.
Original language | English (US) |
---|---|
Pages (from-to) | 3702-3707 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 21 |
Issue number | 13 |
DOIs | |
State | Published - Jul 1 2013 |
Externally published | Yes |
Keywords
- Artemisinin-derived dimmer
- CMV
- Leukemia
- Phosphate ester
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry