TY - JOUR
T1 - Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain
AU - Grau-Perez, Maria
AU - Navas-Acien, Ana
AU - Galan-Chilet, Inmaculada
AU - Briongos-Figuero, Laisa S.
AU - Morchon-Simon, David
AU - Bermudez, Jose D.
AU - Crainiceanu, Ciprian M.
AU - de Marco, Griselda
AU - Rentero-Garrido, Pilar
AU - Garcia-Barrera, Tamara
AU - Gomez-Ariza, Jose L.
AU - Casasnovas, Jose A.
AU - Martin-Escudero, Juan C.
AU - Redon, Josep
AU - Chaves, F. Javier
AU - Tellez-Plaza, Maria
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/4
Y1 - 2018/4
N2 - Inorganic arsenic exposure may be associated with diabetes, but the evidence at low-moderate levels is not sufficient. Polymorphisms in diabetes-related genes have been involved in diabetes risk. We evaluated the association of inorganic arsenic exposure on diabetes in the Hortega Study, a representative sample of a general population from Valladolid, Spain. Total urine arsenic was measured in 1451 adults. Urine arsenic speciation was available in 295 randomly selected participants. To account for the confounding introduced by non-toxic seafood arsenicals, we designed a multiple imputation model to predict the missing arsenobetaine levels. The prevalence of diabetes was 8.3%. The geometric mean of total arsenic was 66.0 μg/g. The adjusted odds ratios (95% confidence interval) for diabetes comparing the highest with the lowest tertile of total arsenic were 1.76 (1.01, 3.09) and 2.14 (1.47, 3.11) before and after arsenobetaine adjustment, respectively. Polymorphisms in several genes including IL8RA, TXN, NR3C2, COX5A and GCLC showed suggestive differential associations of urine total arsenic with diabetes. The findings support the role of arsenic on diabetes and the importance of controlling for seafood arsenicals in populations with high seafood intake. Suggestive arsenic-gene interactions require confirmation in larger studies.
AB - Inorganic arsenic exposure may be associated with diabetes, but the evidence at low-moderate levels is not sufficient. Polymorphisms in diabetes-related genes have been involved in diabetes risk. We evaluated the association of inorganic arsenic exposure on diabetes in the Hortega Study, a representative sample of a general population from Valladolid, Spain. Total urine arsenic was measured in 1451 adults. Urine arsenic speciation was available in 295 randomly selected participants. To account for the confounding introduced by non-toxic seafood arsenicals, we designed a multiple imputation model to predict the missing arsenobetaine levels. The prevalence of diabetes was 8.3%. The geometric mean of total arsenic was 66.0 μg/g. The adjusted odds ratios (95% confidence interval) for diabetes comparing the highest with the lowest tertile of total arsenic were 1.76 (1.01, 3.09) and 2.14 (1.47, 3.11) before and after arsenobetaine adjustment, respectively. Polymorphisms in several genes including IL8RA, TXN, NR3C2, COX5A and GCLC showed suggestive differential associations of urine total arsenic with diabetes. The findings support the role of arsenic on diabetes and the importance of controlling for seafood arsenicals in populations with high seafood intake. Suggestive arsenic-gene interactions require confirmation in larger studies.
KW - Arsenic
KW - Arsenic species
KW - Diabetes
KW - Gene-environment interaction
KW - Multiple imputation
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U2 - 10.1016/j.envpol.2018.01.008
DO - 10.1016/j.envpol.2018.01.008
M3 - Article
C2 - 29751399
AN - SCOPUS:85041672913
SN - 0269-7491
VL - 235
SP - 948
EP - 955
JO - Environmental Pollution
JF - Environmental Pollution
ER -